Results 101 to 110 of about 646,790 (297)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Assessing liquefaction potential in Dhaka: a case study of some reclaimed lands using LPI and Monte Carlo simulation

Smart Construction and Sustainable Cities
Dhaka, the capital of Bangladesh, is one of the largest cities in the world. It is rapidly growing, and new housing areas are being developed by filling water bodies and flood-prone lowlands.
Mohammad Saiful Islam, A. S. M. Sayem, A. S. M. Fahad Hossain   +2 more
doaj   +1 more source

Screening of organically based fungicides for apple scab (Venturia inaequalis) control and a histopathological study of the mode of action of a resistance inducer. [PDF]

, 2005
A range of possible substitutes for copper-based fungicides for control of apple scab (Venturia inaequalis) in organic growing were tested in laboratory and growth chamber experiments in the Danish project StopScab (2002-2004).
Bengtsson, M., Hockenhull, J., Jørgensen, H.J.L., Pham, A., Wulff, E.   +4 more
core  

Standard Penetration Tests and Soil Liquefaction Potential Evaluation

Soils and Foundations, 1980
ABSTRACT Several methods to evaluate cyclic undrained strengths of sandy soils from standard penetration resistances (N-values) are reviewed and compared. It is shown that some empirical equations which do not take account of the effects of grain size on N-values can be rather conservative for fine or silty sands.
Fumio Tatsuoka, Toshio Iwasaki, Ken-Ichi Tokida, Susumu Yasuda, Makoto Hirose, Tsuneo Imai, Masashi Kon-No   +6 more
openaire   +2 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Smart grids for rural conditions and e-mobility - Applying power routers, batteries and virtual power plants [PDF]

, 2016
Significant reductions of greenhouse gas emission by use of renewable energy sources belong to the common targets of the European Union. Smart grids address intelligent use and integration of conventional and renewable generation in combination with ...
Boehner, Volker, Franz, P., Gallart, R, Girbau Llistuella, Francesc, Hanson, J., Martínez, S., Sumper, Andreas   +6 more
core  

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

A micromechanical study of the Standard Penetration Test

, 2023
This thesis explores the potential of models based on the discrete element method (DEM) to study dynamic probing of granular materials, considering realistic particle-scale properties. The virtual calibration chamber technique, based on the discrete element method, is applied to study the standard penetration test (SPT).
openaire   +4 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Study on the performance of ceramic composite projectile penetrating into ceramic composite target

Defence Technology, 2017
In order to study the performance of ceramic composite projectile penetrating into ceramic composite target, the contrast test and numerical simulations of the penetration of standard projectile and the ceramic composite projectile into a ceramic ...
Rong-cheng Yi, Li-kui Yin, Jian-ru Wang, Zhi-gang Chen, Di-qi Hu   +4 more
doaj   +1 more source