Results 61 to 70 of about 198,067 (259)

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Comparing nonlinear regression analysis and ‎artificial neural networks to predict geotechnical ‎parameters from standard penetration test [PDF]

Urbanism. Arhitectura. Constructii, 2018
At the beginning the twenty-first century, a lot of high-level methods have become ‎available in geotechnical engineering in order to deal with the complexity and ‎heterogeneity encountered in soil, Statistical modeling (i.e. regression analysis method) ‎
Mohammed Amin‎ Benbouras, Ratiba Mitiche Kettab, Hamma Zedira, Fatiha Debiche, Narimane Zaidi   +4 more
doaj  

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Assessing liquefaction potential in Dhaka: a case study of some reclaimed lands using LPI and Monte Carlo simulation

Smart Construction and Sustainable Cities
Dhaka, the capital of Bangladesh, is one of the largest cities in the world. It is rapidly growing, and new housing areas are being developed by filling water bodies and flood-prone lowlands.
Mohammad Saiful Islam, A. S. M. Sayem, A. S. M. Fahad Hossain   +2 more
doaj   +1 more source

Integrated Geotechnical and Geophysical Investigation of a Proposed Construction Site at Mowe, Southwestern Nigeria

GeoScience Engineering, 2018
The subsurface of a proposed site for building development in Mowe, Nigeria, using Standard Penetration Test (SPT), Cone Penetrometer Test (CPT) and Horizontal Electrical Profiling (HEP), was investigated with the aim of evaluating the suitability of the
Oyedele Kayode F., Oladele Sunday, Nduka Adaobi C.   +2 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Study on the performance of ceramic composite projectile penetrating into ceramic composite target

Defence Technology, 2017
In order to study the performance of ceramic composite projectile penetrating into ceramic composite target, the contrast test and numerical simulations of the penetration of standard projectile and the ceramic composite projectile into a ceramic ...
Rong-cheng Yi, Li-kui Yin, Jian-ru Wang, Zhi-gang Chen, Di-qi Hu   +4 more
doaj   +1 more source