Results 71 to 80 of about 208,631 (258)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

CPT- and SPT-based probabilistic liquefaction assessment using adaptive kernel density estimation

KSCE Journal of Civil Engineering
This study introduces a simplified stress-based model that enables quick assessment of the probability of liquefaction (PL) and post-liquefaction volumetric strain (εvol).
Javad Sadoghi Yazdi, Javad Jafari, Hadi Sadoghi Yazdi   +2 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Integrated Geotechnical and Geophysical Investigation of a Proposed Construction Site at Mowe, Southwestern Nigeria

GeoScience Engineering, 2018
The subsurface of a proposed site for building development in Mowe, Nigeria, using Standard Penetration Test (SPT), Cone Penetrometer Test (CPT) and Horizontal Electrical Profiling (HEP), was investigated with the aim of evaluating the suitability of the
Oyedele Kayode F., Oladele Sunday, Nduka Adaobi C.   +2 more
doaj   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Analisis Potensi Likuifaksi Akibat Gempa Bumi Menggunakan Metode SPT (Standar Penetration Test) Dan Cpt (Cone Penetration Test) Di Kabupaten Bantul, Yogyakarta

Wahana Fisika: Jurnal Penelitian Fisika dan Terapannya, 2017
Gempa bumi yang terjadi di daerah Bantul, Yogyakarta pada 27 Mei 2006 dengan magnitudo gempa bumi sebesar 6.3 SR dapat menyebabkan terjadinya bahaya likuifaksi yang dapat merusak bangunan khususnya di wilayah Bantul Yogyakarta. Investigasi geoteknik yang
Tini, Adrin Tohari, Mimin Iryanti
doaj  

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

A Metaheuristic-Trained Wavelet Neural Network for Predicting of Soil Liquefaction Based on the Standard Penetration Test Results [PDF]

Journal of Soft Computing in Civil Engineering
Earthquake-induced soil liquefaction is one of the natural hazards that can cause irreparable damages to buildings and infrastructure in addition to threatening human lives.
Ali Reza Ghanizadeh, Ahmad Aziminejad
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source