Results 171 to 180 of about 1,377,237 (309)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Evaluation of Applying Standardized Patients in Certification Assessment of Clinical Practice Ability Standardized Training for Psychiatric Resident Physicians

Advances in Medical Education and Practice
Fei Yao,1,2,* Jian-Song Chen,1,2,* Li-Hong Chen,1,2 Bi-Yu Ye,1,2 Chan-Juan Yang,1,2 Xuan-Zi Li1,2 1Department of Education, The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, Guangdong, 510370, People’s Republic of China ...
Yao F, Chen JS, Chen LH, Ye BY, Yang CJ, Li XZ   +5 more
doaj  

Effectiveness evaluation of standardized patient training system on emergency department residents in disposing patients with acute chest pain. [PDF]

BMC Med Educ
Lu F, Huang T, Chen R, Wang Y, Yin H.
europepmc   +1 more source

Causes of pediatric mortality and case-fatality rates in eight Médecins Sans Frontières-supported hospitals in Africa [PDF]

, 2012
Harries, A D, Manzi, M, Reid, A J, van den Boogaard, W   +3 more
core   +2 more sources

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Evaluating medical students' engagement and confidence across three simulation-based education methods: standardized patient, high fidelity simulator, and virtual reality. [PDF]

BMC Med Educ
Yu J, Lee S, Kim M, Lee J, Jung YJ.
europepmc   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Comparing Artificial Intelligence and Obstetrics Residents in Answering Standardized Patient Questions Regarding Gestational Diabetes. [PDF]

Cureus
Faraji A, Faramarzi H, Razeghi M, Asadi N, Vafaei H, Kasraeian M.   +5 more
europepmc   +1 more source

Necrotizing Fasciitis [PDF]

, 2020
Desta, Rishan, Yee, Jennifer
core