Results 151 to 160 of about 1,661,930 (349)

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Generalizing univariate signed rank statistics for testing and estimating a multivariate location parameter. [PDF]

We generalize signed rank statistics to dimensions higher than one. This results in a class of orthogonally invariant and distribution free tests that can be used for testing spherical symmetry/location parameter.
Croux, C., Hössjer, O.
core  

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Supplementary Material for: The Single-Matrix Digit Cancellation Test (SMDCT), a screener for selective attention deficits: standardization in an Italian population sample and clinical usability in acute stroke patients

, 2023
Fabrizio Pasotti, E.N., Aiello, Alessandra Bollani, Matteo Querzola, S. Cozzi, Francesca Manfrin, Stefania Bruno, Barbara Poletti, Nicola Ticozzi, Vincenzo Silani, Gabriella Bottini   +10 more
openalex   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

MacArthur-Bates Communicative Development Inventories. A Possible Means of Lexical Longitudinal Assessment of Very Young EFL learners

RATE Issues
Progress reports are one of the documents beginner Romanian teachers of English need to have included in their portfolios. Unfortunately, measuring progress is not as easy as it looks at first glance, as teachers need a testing tool that can be used ...
Cristina Alexandrescu
doaj  

Immune Functional Assays, From Custom to Standardized Tests for Precision Medicine. [PDF]

Front Immunol, 2018
Albert-Vega C, Tawfik DM, Trouillet-Assant S, Vachot L, Mallet F, Textoris J.   +5 more
europepmc   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Taking tests in the magnet: Brain mapping standardized tests. [PDF]

Hum Brain Mapp, 2017
Rubin DC, Li D, Hall SA, Kragel PA, Berntsen D.   +4 more
europepmc   +1 more source

Establishing Standardized Criteria to Improve the Interpretation of Genetic Testing for Ocular Disorders

, 2021
Kristy Lee, Emily Place, Radha Ayyagari, Rui Chen, Kerry Goetz, Robert B. Hufnagel, Linda M. Reis, Susanne Roosing, Emmanuelle Souzeau, Patrick Yu‐Wai‐Man, Brian C. Mansfield, Janey L. Wiggs   +11 more
openalex   +1 more source