Results 161 to 170 of about 767,925 (267)

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

APKASS 2024 consensus statement on anterior cruciate ligament reconstruction, part Ⅲ: Return to play after anterior cruciate ligament reconstruction. [PDF]

Asia Pac J Sports Med Arthrosc Rehabil Technol
Liang Z, Hoshino Y, Moatshe G, Wang JH, Issaragrisil P, Mogos S, Saengpetch N, Phornphutkul C, Kim JG, Kuroda R, Kulkamthorn N, Koga H, Otsuki S, Akagi R, Lee SH, Eriksson K, Yoon KH, Chernchujit B, Keyurapan E, Raoulis V, Siebold R, Ng JP, Yung PS, Ong MT.   +23 more
europepmc   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Smartphone Sensor Battery Consumption: A Standardized and Reproducible Test Protocol. [PDF]

Sensors (Basel)
Schweizer F, Yu J, Mille E, Reimer LM, Kapsecker M, Klinker J, Jonas S.   +6 more
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Dynamics of sociopolitical polarization and effects of misperception-correcting information around the 2022 Brazilian elections. [PDF]

Nat Commun
Petherick A, Ramos GA, Furst R, Goldszmidt R, Andrade EB.   +4 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Integrating Mind Mapping with Virtual Simulation: A Cognitive Scaffolding for Clinical Reasoning in Residency. [PDF]

Int J Womens Health
Chen Q, Xi F, Lv M.
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Quantitative magnetic resonance imaging during knee hyperextension for the evaluation of screw-home mechanism abnormalities in patients with anterior cruciate ligament injury: a clinical study. [PDF]

Quant Imaging Med Surg
Li Z, Chen W, Chen J, Tan X, Li S.
europepmc   +1 more source