Results 91 to 100 of about 1,226,092 (307)

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Application of online to offline teaching mode in the training of non-anesthesiology residents in the department of anesthesiology: a randomized, controlled trial

Frontiers in Medicine
ObjectiveTo explore the effect of applying the online to offline teaching mode in the training of non-anesthesiology residents in department of anesthesiology.Trial designThe randomized controlled trial was performed on non-anesthesiology residents from ...
Yuan-yuan Zhao, Ting-ting Zhang, Ling-hui Li, Qian Liu, Li-juan Peng, Qi Wang, Wei Wang, Wan-you Yu   +7 more
doaj   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

Transesophageal echocardiography: Revolutionizing perioperative cardiac care

Biomolecules & Biomedicine
Cardiovascular diseases (CVDs) are a major challenge in global health. Despite significant advances in treatment and management, the incidence and mortality rates of CVDs have been rising in recent years, particularly in the United States.
Jiuqing Liang, Xiaoyu Ma, Genqiang Liang   +2 more
doaj   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Study of EVA operations associated with satellite services [PDF]

Extravehicular mobility unit (EMU) factors associated with satellite servicing activities are identified and the EMU improvements necessary to enhance satellite servicing operations are outlined.
Nash, J. O., Wilde, R. D.
core   +1 more source

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

Teaching practice of endotracheal intubation in emergency department standardized residency training guided by the outcome-based education concept

Neike lilun yu shijian
ObjectiveTo evaluate the effect of outcome-based education (OBE) approach on endotracheal intubation training for emergency department residents during the standardized residency training.
Min CHEN, Huiqiu SHENG, Zhitao YANG, Weijun ZHOU, Enqiang MAO   +4 more
doaj   +1 more source

Analysis of the correlation between core competencies of pediatric nurses and occupational benefit perception and its influencing factors

Frontiers in Pediatrics
PurposeAnalyzed the correlation between core competencies and career benefits in pediatric nurse specialists, and examined the factors influencing core competencies in pediatric nurse specialists.
Huihui Zhang, Jianxin Wang, Chunhui Li, Xinyu Liu, Qianmei Xiang   +4 more
doaj   +1 more source

The Influence of Intensity Standardization on Medical Image Registration

, 2010
Acquisition-to-acquisition signal intensity variations (non-standardness) are inherent in MR images. Standardization is a post processing method for correcting inter-subject intensity variations through transforming all images from the given image gray ...
Bagci, Ulas, Bai, Li, Udupa, Jayaram K.
core   +1 more source