Results 71 to 80 of about 1,237,785 (303)

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Exploring and practicing “integrated residency and fellowship teaching rounds” in neurology

Neike lilun yu shijian
The standardized fellowship and the standardized residency training are important components of China's post-graduation medical education system. According to the national guidelines for standardized fellowship, it is necessary to establish a structured ...
Xiaodong YANG, Yuyan TAN, Rujing REN, Yi FU, Jun LIU, Xiaoyang LI   +5 more
doaj   +1 more source

Enhancing first-attempt success in radial artery cannulation: a PDCA-driven approach for anesthesiology residency training

Frontiers in Surgery
ObjectiveThis study aimed to evaluate the effectiveness of the Plan-Do-Check-Act (PDCA) cycle in improving the first-attempt success rate of radial artery cannulation among anesthesiology residents undergoing standardized training.MethodsEighty-six ...
Meng Zhang, Shuchuan Zhao, Fangjing Bai, Shanshan Yu, Huixian Zhou, Siyuan Song, Guangmin Xu   +6 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

The “Hand as Foot” teaching method in the anatomy of abdominal muscles: A classic medical pithy formula

Asian Journal of Surgery, 2023
Muhua Zhang, Honglei Li, Wei Gao, Jizhou Shi   +3 more
doaj   +1 more source

Classification of lower extremity movement patterns based on visual assessment: reliability and correlation with 2-dimensional video analysis [PDF]

, 2014
CONTEXT: Abnormal movement patterns have been implicated in lower extremity injury. Reliable, valid, and easily implemented assessment methods are needed to examine existing musculoskeletal disorders and investigate predictive factors for lower extremity
Graci, Valentina, Harris-Hayes, Marcie, Koh, Christine, Royer, Nathaniel K, Salsich, Gretchen B, Steger-May, Karen   +5 more
core   +2 more sources

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

The “Hand as Foot” teaching method in Angle's classification of malocclusion

Asian Journal of Surgery, 2023
Zhiwei Xie, Fuying Yang, Sujuan Liu, Min Zong   +3 more
doaj   +1 more source

Application of digital teaching mode in outpatient general practice professional master training [PDF]

Yixue xinzhi zazhi
General practitioners are the backbone of primary health care, responsible for the diagnosis and treatment of common diseases, the rational diversion of medical resources and continuous medical services. The "5+3" model adopted in the training of general
WANG Hong, LI Yanhua
doaj   +1 more source