Results 161 to 170 of about 24,475 (286)

Genetic recombination-mediated evolutionary interactions between phages of potential industrial importance and prophages of their hosts within or across the domains of Escherichia, Listeria, Salmonella, Campylobacter, and Staphylococcus

open access: yesBMC Microbiology
Background The in-depth understanding of the role of lateral genetic transfer (LGT) in phage-prophage interactions is essential to rationalizing phage applications for human and animal therapy, as well as for food and environmental safety. This in silico
Saba Kobakhidze   +3 more
doaj   +1 more source

The Arms Race Between Actinobacillus pleuropneumoniae and Its Genetic Environment: A Comprehensive Analysis of Its Defensome and Mobile Genetic Elements

open access: yesMolecular Microbiology, EarlyView.
Using bioinformatic tools, we identified a diverse defensome in Actinobacillus pleuropneumoniae, featuring various defense mechanisms. Genomes show co‐occurring systems like CRISPR, Abi, and restriction‐modification (RM) systems, underscoring the complexity and dynamic nature of their defensome cargo.
Giarlã Cunha da Silva   +1 more
wiley   +1 more source

Genome‐Wide Analysis of DtxR and HrrA Regulons Reveals Novel Targets and a High Level of Interconnectivity Between Iron and Heme Regulatory Networks in Corynebacterium glutamicum

open access: yesMolecular Microbiology, EarlyView.
Iron is essential for life, yet excessive levels can quickly lead to cellular damage via oxidative stress, underscoring the need for global regulators of iron and heme homeostasis. In this study, we present a genome‐wide analysis of the binding patterns of DtxR and HrrA in Corynebacterium glutamicum.
Aileen Krüger   +2 more
wiley   +1 more source

Mechanisms governing bacterial capsular polysaccharide attachment and chain length

open access: yesAnnals of the New York Academy of Sciences, EarlyView.
Abstract Capsular polysaccharides (CPSs) are high‐molecular weight glycopolymers that form a capsule layer on the surface of many bacterial species. This layer serves as a crucial barrier between bacteria and their environment, protecting them from host immune responses and environmental stressors while facilitating adaptation to host niches.
Saroj Khadka   +3 more
wiley   +1 more source

Fighting Antibiotic Resistance: Insights Into Human Barriers and New Opportunities

open access: yesBioEssays, Volume 47, Issue 6, June 2025.
Antibiotic resistance is a public health issue leading to the emergence of multi‐resistant bacteria. Human‐dependent factors are now driving the increase of resistance, notably through antibiotic misuse in human and animal health and environmental pollution.
Aubin Pitiot   +3 more
wiley   +1 more source

Self-assembling T7 phage syringes with modular genomes for targeted delivery of penicillin against beta-lactam-resistant Escherichia coli [PDF]

open access: yesarXiv
Bacteriophages are promising alternative antimicrobial agents due to their high specificity for host bacteria and minimal immunogenicity in humans. However, their therapeutic application is limited by their nature as biological entities, which can lead to unintended evolutionary consequences such as horizontal gene transfer.
arxiv  

Towards the Understanding of Stability Puzzles in Phage lambda [PDF]

open access: yesarXiv, 2003
We discuss two aspects, the in vivo and in vitro difference and the modeling of noise, of integrative modeling of network dynamics in biology, using phage lambda as an example. We believe those two aspects have not been seriously considered, and the including of them may be enough to solve the outstanding stability and robustness puzzle of in gene ...
arxiv  

Bacterial Outer Membrane Vesicles: From Physics to Clinical

open access: yesMedComm – Biomaterials and Applications, Volume 4, Issue 2, June 2025.
A review of an introduction to the mechanisms of formation of OMVs, their action on bacteria and relationship to disease, vaccines, biomonitoring, drug delivery and regenerative medicine in the clinic. ABSTRACT Bacterial outer membrane vesicles (OMVs) are nanoscale vesicular structures naturally produced by Gram‐negative bacteria during growth.
Jun Zhou   +7 more
wiley   +1 more source

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