Results 61 to 70 of about 27,160 (297)
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Soil & Environment, 2009 Foliar application of boron improves seed cotton yield and fiber traits. A field experiment was conducted to study the effects of foliar application of 37 grams of boron (B) per acre (91.4 g ha-1) on quality and quantity of cotton (Gossypium hirsutum L.
S. Ahmad +4 more
doaj
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Journal of Cotton Research, 2020 Background Cotton is known for fiber extraction and it is grown in tropical and sub-tropical areas of the world due to having hot weather. Cotton crop has a significant role in GDP of Pakistan.
Abdul REHMAN +3 more
doaj +1 more source
Two-way selection for staple length in fine-wooled sheep
, 2012 Materials; Methods; Selection for longer staple; Changes in the ewe herd; Changes in the ewe lambs; Selection for shorter staple; Changes in the ewe herd; Changes in the ewe lambs; Literature citedResearch report containing the results of experiments to ...
McFadden, Wm. D. (William D.); Pope, Joseph T., 1950-
core
Study on Java Kapok Fruit and Fiber Length
, 2011 The study focused on structure and fiber length of Java kapok fruit from Pate County, Java Tengah in Indonesia for effective utilization. The internal structure of Java kapok fruit can be divided into two parts: fiber bundle and combination of short ...
Feng Tan, Hong Yan Wu, Fu Mei Wang
core +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Engineering of brick and staple components for ordered assembly of synthetic repeat proteins
, 2023 International audienceSynthetic ɑRep repeat proteins are engineered as Brick and Staple protein pairs that together self-assemble into helical filaments. In most cases, the filaments spontaneously form supercrystals.
Erik Dujardin +19 more
core +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source