Results 121 to 130 of about 429,563 (275)

The Steady State Wind Model for Young Stellar Clusters with an Exponential Stellar Density Distribution

, 2011
A hydrodynamic model for steady state, spherically-symmetric winds driven by young stellar clusters with an exponential stellar density distribution is presented.
Bisnovatyi-Kogan, Böker, Cantó, Gennadiy Bisnovatyi-Kogan, Guillermo Tenorio-Tagle, Law, Leitherer, Moffat, Raga, Rockefeller, Rupke, Sergio Martínez-González, Sergiy Silich, Silich, Silich, Silich, Silich, Tenorio-Tagle, Townsley, Turner, Walcher, Wünsch, Wünsch   +22 more
core   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

The ACS Nearby Galaxy Survey Treasury. X. Quantifying the Star Cluster Formation Efficiency of Nearby Dwarf Galaxies

, 2012
We study the relationship between the field star formation and cluster formation properties in a large sample of nearby dwarf galaxies. We use optical data from the Hubble Space Telescope and from ground-based telescopes to derive the ages and masses of ...
Anil C. Seth, Bastian, Bertelli, Billett, Boselli, Bressan, Bressert, Buat, Chandar, Chandar, Chandar, Charles W. Engelbracht, da Silva, Dalcanton, Dale, Dale, Daniel A. Dale, Daniel R. Weisz, David O. Cook, Dohm-Palmer, Evans, Fall, Fall, Fioc, Fouesneau, Fumagalli, Gieles, Girardi, Goddard, Groenewegen, Hunter, Hunter, Hunter, Hénon, Julianne J. Dalcanton, Karachentsev, Kennicutt, Knut A. G. Olsen, Kroupa, L. Clifton Johnson, Larsen, Larsen, Lee, Lee, Leroy, Marble, Maíz Apellániz, McCrady, McQuinn, Meurer, Morgan Fouesneau, Moustakas, Muñoz-Mateos, Popescu, Porras, Schlegel, Weisz, Weisz, Weisz, Whitmore, Whitmore, Zhang   +61 more
core   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

A star cluster at the edge of the Galaxy [PDF]

, 2006
J. Brand, J. G. A. Wouterloot
openalex   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Testing Cluster Membership of Planetary Nebulae with High-precision Proper Motions. I. HST Observations of JaFu 1 Near the Globular Cluster Palomar 6

The Astronomical Journal
If a planetary nebula (PN) is shown to be a member of a star cluster, we obtain important new constraints on the mass and chemical composition of the PN’s progenitor star, which cannot be determined for PNe in the field.
Howard E. Bond, Andrea Bellini, Kailash C. Sahu   +2 more
doaj   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Star Clusters

, 2006
Star clusters are observed in almost every galaxy. In this thesis we address several fundamental problems concerning the formation, evolution and disruption of star clusters. From observations of (young) star clusters in the interacting galaxy M51, we found that clusters are formed in complexes of stars and star clusters.
openaire   +2 more sources

Star Clusters [PDF]

, 1994
This review concentrates almost entirely on globular star clusters. It emphasises the increasing realisation that few of the traditional problems of star cluster astronomy can be studied in isolation: the influence of the Galaxy affects dynamical evolution deep in the core, and the spectrum of stellar masses; in turn the evolution of the core ...
openaire   +2 more sources