Results 81 to 90 of about 91,664 (267)
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Massive Star Birth in the Inner Galaxy: Obscured Massive Star Clusters [PDF]
, 2001 Robert Blum +3 more
openalex +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
The Astrophysical Journal LettersDense stellar clusters surround the supermassive black holes (SMBH) in galactic nuclei. Interactions within the cluster can alter the stellar orbits, occasionally driving a star into the SMBH’s tidal radius, where it becomes ruptured, or expelling a star
Sanaea C. Rose, Brenna Mockler
doaj +1 more source
VERTICO IV: Environmental Effects on the Gas Distribution and Star Formation Efficiency of Virgo Cluster Spirals [PDF]
, 2022 Vicente Villanueva +20 more
openalex +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
The Astrophysical Journal LettersThe rapid quenching of satellite galaxies in dense environments is often attributed to environmental processes such as ram pressure stripping. However, stripping alone cannot fully account for the removal of dense, star-forming gas in many satellites ...
Amy Attwater +12 more
doaj +1 more source
LoTSS Jellyfish Galaxies IV: Enhanced Star Formation on the Leading Half of Cluster Galaxies and Gas Compression in IC3949 [PDF]
, 2022 Ian Roberts +9 more
openalex +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
High Velocity Oblique Cloud Collision and Star and Star Cluster Formation through Gravitational Instability of the Shock-Compressed Slab with Rotation and Velocity Shear [PDF]
, 1994 Masatoshi Usami +2 more
openalex +1 more source