Results 101 to 110 of about 71,711 (296)

Response to neoadjuvant chemotherapy in early breast cancers is associated with epithelial–mesenchymal transition and tumor‐infiltrating lymphocytes

open access: yesMolecular Oncology, EarlyView.
Epithelial–mesenchymal transition (EMT) and tumor‐infiltrating lymphocytes (TILs) are associated with early breast cancer response to neoadjuvant chemotherapy (NAC). This study evaluated EMT and TIL shifts, with immunofluorescence and RNA sequencing, at diagnosis and in residual tumors as potential biomarkers associated with treatment response.
Françoise Derouane   +16 more
wiley   +1 more source

Disk-locking Regulates Stellar Rotation in Young Clusters: Insights from NGC 2264

open access: yesThe Astrophysical Journal
Many young clusters possess extended main sequences, a phenomenon commonly ascribed to stellar rotation. However, the mechanism behind their very wide stellar rotation distributions remains unclear.
Yutian Bu   +3 more
doaj   +1 more source

Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression

open access: yesMolecular Oncology, EarlyView.
Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park   +6 more
wiley   +1 more source

Star formation in clusters

open access: yes, 2006
HST is very well tailored for observations of extragalactic star clusters. One obvious reason is HST's high spatial resolution, but equally important is the wavelength range offered by the instruments on board HST, in particular the blue and near-UV coverage which is essential for age-dating young clusters.
openaire   +3 more sources

Adverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...
Marina N. Sharifi   +26 more
wiley   +1 more source

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

open access: yesMolecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam   +9 more
wiley   +1 more source

oMEGACat. IV. Constraining the Ages of Omega Centauri Subgiant Branch Stars with HST and MUSE

open access: yesThe Astrophysical Journal
We present age estimates for over 8100 subgiant branch (SGB) stars in Omega Centauri ( ω Cen) to study its star formation history. Our large data set, which combines multi-wavelength Hubble Space Telescope photometry with MUSE metallicities, provides an ...
C. Clontz   +15 more
doaj   +1 more source

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