Results 81 to 90 of about 75,652 (263)
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Forest Fire Clustering: A Novel Tool for Identifying Star Members of Clusters
The Astronomical JournalIn the era of a data-driven landscape, the development of an efficient and interpretable method has become a pivotal tool for robustly identifying memberships of clusters.
Xingyin Wei +8 more
doaj +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
The Astrophysical JournalAge-benchmark brown dwarf and planetary-mass-object spectroscopy is key to characterizing substellar evolution. In this paper, we present the JHK medium-resolution ( R ∼ 3000) spectra of 25 7–76 M _Jup (spectral types L3.0–M6.0) brown dwarfs and ...
Elena Manjavacas +5 more
doaj +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
The Astrophysical JournalYoung massive clusters (YMCs) are dense aggregates of young stars and are often speculated as potential precursors to globular clusters. However, the formation mechanism of massive and compact gas clumps that precede YMCs remains unknown.
Ryunosuke Maeda +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source
The Spatial Distribution of Intracluster Globular Clusters in the Fornax Cluster
The Astrophysical JournalWe investigate the spatial distribution of the intracluster globular clusters (ICGCs) detected in the core of the Fornax galaxy cluster. By separately modeling different components of the observed population of globular clusters (GCs), we confirm the ...
Raffaele D’Abrusco +8 more
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source