Results 81 to 90 of about 352,865 (294)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The Velocity Dispersion Profile of Nine Open Clusters in the Solar Neighborhood

The Astrophysical Journal
We analyze the velocity dispersion profiles of nine open clusters in the solar neighborhood using kinematic data from Gaia DR 3, aiming to identify potential dynamical signatures of stellar-mass black holes through a comparison of theoretical and ...
Bingqian Ma, Xiaoying Pang, Sambaran Banerjee, Pengfei Ren, M. B. N. Kouwenhoven   +4 more
doaj   +1 more source

Two Populations of Molecular Clouds in the Antennae Galaxies

, 2012
Super star clusters --- extremely massive clusters found predominately in starburst environments --- are essential building blocks in the formation of galaxies and thought to dominate star formation in the high-redshift universe.
Ashman, Bastian, Bolatto, Braine, Brandl, Brogan, Cen, Elmegreen, Eric Keto, Evans, Fabbiano, Fabbiano, Fall, Gao, Gao, Gao, Heyer, Hibbard, Hibbard, Ho, Ho, Ho, Ho, Keto, Kilgard, Larson, Lisa H. Wei, Luis C. Ho, McCrady, Melo, Mirabel, Neff, Oka, Oka, Pahre, Pineda, Renaud, Sault, Sawada, Schweizer, Sheth, Snijders, Solomon, Ueda, van den Bergh, Wang, Whitmore, Whitmore, Wilson, Wilson, Wu, Zepf, Zezas, Zezas, Zhang, Zhang, Zhu   +56 more
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Rotation and Hα Emission in a Young SMC Cluster: A Spectroscopic View of NGC 330

The Astrophysical Journal
We present an analysis of high-resolution optical spectra recorded for 30 stars of the split extended main-sequence turnoff of the young (∼40 Myr) Small Magellanic Cloud globular cluster NGC 330.
Paul I. Cristofari, Andrea K. Dupree, Antonino P. Milone, Matthew G. Walker, Mario Mateo, Aaron Dotter, John I. Bailey III   +6 more
doaj   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Massive Star Cluster Formation with Binaries. I. Evolution of Binary Populations

The Astrophysical Journal
We study the evolution of populations of binary stars within massive cluster-forming regions. We simulate the formation of young massive star clusters within giant molecular clouds with masses ranging from 2 × 10 ^4 to 3.2 × 10 ^5 M _⊙ .
Claude Cournoyer-Cloutier, Alison Sills, William E. Harris, Brooke Polak, Steven Rieder, Eric P. Andersson, Sabrina M. Appel, Mordecai-Mark Mac Low, Stephen McMillan, Simon Portegies Zwart   +9 more
doaj   +1 more source

Star formation activities in early-type brightest cluster galaxies

, 2012
We identify a total of 120 early-type Brightest Cluster Galaxies (BCGs) at 0 ...
Allen, Alongi, Baldwin, Bauer, Bernardi, Bernardi, Bildfell, Bressan, Bruzual, Böhringer, Böhringer, Calzetti, Calzetti, Calzetti, Cardiel, Cavagnolo, Chabrier, Cid Fernandes, Crawford, De Lucia, Desroches, Donahue, Dressler, Dunn, Edge, Edwards, Egami, F. S. Liu, Fagotto, Fagotto, Gao, Girardi, Graham, Hao, Hao, Hatch, Hicks, Hicks, Huang, Jeltema, Jones, Kauffmann, Kauffmann, Kauffmann, Kauffmann, Kaviraj, Kaviraj, Kennicutt, Kewley, Kewley, Kim, Lauer, Lauer, Liu, Liu, Liu, Matthews, McDonald, McIntosh, McNamara, Meng, Mulchaey, Oemler, Oemler, O’Dea, O’Dea, Patel, Pipino, Poole, Rafferty, Rines, Schawinski, Schombert, Schombert, Schombert, Shude Mao, Smith, Stott, Szabo, Thomas, Tran, Tran, van Dokkum, Voges, Voges, von der Linden, Wang, Wang, Wen, Whiley, Wilman, X. M. Meng   +91 more
core   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source