Results 81 to 90 of about 1,296,799 (301)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

The Spectroscopic and Photometric Study of a Star Cluster Sample in Andromeda Halo

The Astronomical Journal
Halo star clusters serve as vital tracers for the formation and evolution of the Andromeda galaxy. In this work, we present physical parameters for 29 M31 halo star clusters, derived from a combination of spectroscopic and photometric data.
Hongrui Gu, Zhou Fan, Bingqiu Chen, Xiaoying Pang, Juanjuan Ren, Ruizheng Jiang, Song Wang, Kefeng Tan, Nan Song, Chun Li, Jie Zheng, Gang Zhao, Wei Wang, Yuqin Chen, Jingkun Zhao, Haining Li, Yihan Song, Haibo Yuan, Ali Luo, Yujuan Liu, Yaqian Wu   +20 more
doaj   +1 more source

An Investigation of Open Clusters Berkeley 68 and Stock 20 Using CCD UBV and Gaia DR3 Data

The Astronomical Journal, 2023
We performed detailed photometric and astrometric analyses of the open star clusters Berkeley 68 and Stock 20. This was based on ground-based CCD UBV photometric data complemented by space-based Gaia Data Release 3 (DR3) photometry and astrometry.
Talar Yontan
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Utilizing Voronoi Tessellations to Determine Radial Density Profiles

The Astronomical Journal
We have developed a novel method of determining 2D radial density profiles for astronomical systems of discrete objects using Voronoi tessellations. This Voronoi-based method was tested against the standard annulus-based method on five simulated systems ...
Veronika Dornan, William E. Harris
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Emergence of a Lithium Dip in ∼35 Myr “Snake” Open Clusters

The Astrophysical Journal Letters
We report the discovery of a lithium dip (Li dip) in the stellar “Snake” (age = 35 ± 5 Myr), challenging the classical view that Li dips emerge only at ages ≳150 Myr.
Yun-Yi Zhang, Hai-Jun Tian, Jian-Rong Shi, Cheng-Cheng Xie, Xiang-Ming Yang   +4 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Star formation in clusters

, 2006
HST is very well tailored for observations of extragalactic star clusters. One obvious reason is HST's high spatial resolution, but equally important is the wavelength range offered by the instruments on board HST, in particular the blue and near-UV coverage which is essential for age-dating young clusters.
openaire   +2 more sources

On the Roles of Stellar Rotation and Binarity in NGC 2423's Main-sequence Turnoff Region

The Astrophysical Journal
Research has shown that many young and intermediate-age clusters (younger than ∼2 Gyr) have extended main sequences and extended main-sequence turnoffs (eMSTOs), which cannot be adequately described by a single isochrone. The reason for the extended main
Yutian Bu, Chenyu He, Li Wang, Jiamao Lin, Chengyuan Li   +4 more
doaj   +1 more source