Results 71 to 80 of about 75,652 (263)
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
The Star Clusters as Links between Galaxy Evolution and Star Formation Project. I. Numerical Method
The Astrophysical JournalStellar clusters are critical constituents within galaxies: They are the result of highest-density star formation, and through their spatially and temporally correlated feedback, they regulate their host galaxy evolution.
Marta Reina-Campos +3 more
doaj +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
PSR J1922+37: a 1.9 s Pulsar Discovered in the Direction of the Old Open Cluster NGC 6791
The Astrophysical Journal LettersMore than 300 pulsars have been discovered in Galactic globular clusters; however, none have been found in open clusters. Here we present results from a 20 hr survey of seven open clusters with the Five-hundred-meter Aperture Spherical radio Telescope ...
Xiao-Jin Liu +10 more
doaj +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Revisiting Open Clusters within 200 pc in the Solar Neighborhood with Gaia DR3
The Astronomical JournalIn this study, we develop a membership identification method and apply it for 30 open clusters (OCs) within 200 pc of the Sun using astrometric data of Gaia DR3.
Penghui Liu +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
The Astronomical JournalWe present the results from spectroscopic and photometric analysis of 17 globular cluster (GC) candidates in the Irr II galaxy NGC 3077. The GC candidates were selected on the Hubble Space Telescope images and were cleaned of foreground Galatic stars ...
P. A. Ovando +6 more
doaj +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
VLA 22 GHz Imaging of Massive Star Formation in Local Wolf–Rayet Galaxies
The Astrophysical JournalWe present 22 GHz imaging of regions of massive star formation within the Local Wolf–Rayet Galaxy Sample, a NSF Karl G. Jansky Very Large Array survey of 30 local galaxies showing spectral features of Wolf–Rayet (WR) stars.
Nicholas G. Ferraro +6 more
doaj +1 more source