Results 111 to 120 of about 1,165,937 (254)

Technoligical Life Cycles Regional Clusters Facing Disruption [PDF]

The phenomenon of technological life cycles is argued to be of great importance in the development of regional clusters. New 'disruptive' technologies may initiate the emergence of new regional industrial clusters and/or create new opportunities for ...
Gert Villumsen, Bent Dalum, Christian Ø.R. Pedersen   +2 more
core  

The Impact of Stellar Radiative Feedback on Formation of Young Massive Clusters via Fast H i Gas Collisions

The Astrophysical Journal
Young massive clusters (YMCs) are dense aggregates of young stars and are often speculated as potential precursors to globular clusters. However, the formation mechanism of massive and compact gas clumps that precede YMCs remains unknown.
Ryunosuke Maeda, Tsuyoshi Inoue, Kazuyuki Omukai, Yasuo Fukui, Kisetsu Tsuge   +4 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

The Spatial Distribution of Intracluster Globular Clusters in the Fornax Cluster

The Astrophysical Journal
We investigate the spatial distribution of the intracluster globular clusters (ICGCs) detected in the core of the Fornax galaxy cluster. By separately modeling different components of the observed population of globular clusters (GCs), we confirm the ...
Raffaele D’Abrusco, Marco Mirabile, Michele Cantiello, Enrica Iodice, Avinash Chaturvedi, Michael Hilker, Giuseppina Fabbiano, Marilena Spavone, Maurizio Paolillo   +8 more
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Revisit of 77 Clusters Candidates with Multiple Main Sequences using Gaia DR3

The Astronomical Journal
Gaia DR3 data provide the latest and full astrometric data for more than 1.5 billion sources, and these allow us to revisit the 77 special open cluster candidates collected from LISC star cluster catalog.
Jing Chen, Zhongmu Li, Su Zhang, Wenchang Zhao, You Wu   +4 more
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Star formation and chemical enrichment for globular clusters

, 2001
A model considering gas outflows due to supernova explosions is developed for the star formation and chemical enrichment for the globular clusters (GCs) in the Milky Way galaxy.
Lin, Q, Shu, CG, Zhao, JL, Chang, RX
core