Results 51 to 60 of about 71,766 (252)

Star Clusters [PDF]

, 1994
This review concentrates almost entirely on globular star clusters. It emphasises the increasing realisation that few of the traditional problems of star cluster astronomy can be studied in isolation: the influence of the Galaxy affects dynamical evolution deep in the core, and the spectrum of stellar masses; in turn the evolution of the core ...
openaire   +2 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Rotation and Hα Emission in a Young SMC Cluster: A Spectroscopic View of NGC 330

The Astrophysical Journal
We present an analysis of high-resolution optical spectra recorded for 30 stars of the split extended main-sequence turnoff of the young (∼40 Myr) Small Magellanic Cloud globular cluster NGC 330.
Paul I. Cristofari, Andrea K. Dupree, Antonino P. Milone, Matthew G. Walker, Mario Mateo, Aaron Dotter, John I. Bailey III   +6 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Massive Star Cluster Formation with Binaries. I. Evolution of Binary Populations

The Astrophysical Journal
We study the evolution of populations of binary stars within massive cluster-forming regions. We simulate the formation of young massive star clusters within giant molecular clouds with masses ranging from 2 × 10 ^4 to 3.2 × 10 ^5 M _⊙ .
Claude Cournoyer-Cloutier, Alison Sills, William E. Harris, Brooke Polak, Steven Rieder, Eric P. Andersson, Sabrina M. Appel, Mordecai-Mark Mac Low, Stephen McMillan, Simon Portegies Zwart   +9 more
doaj   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Semiempirical versus Theoretical Stellar Population Models: A Comparison with Star Clusters

The Astronomical Journal
Stellar population synthesis (SPS) models are a key tool for deriving the age, metallicity, radial velocity, and reddening of star clusters from their integrated spectra.
Randa Asa’d, Paula R. T. Coelho, Johina M. John, Igor V. Chilingarian, Gustavo Bruzual, Stephane Charlot   +5 more
doaj   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

PSR J1922+37: a 1.9 s Pulsar Discovered in the Direction of the Old Open Cluster NGC 6791

The Astrophysical Journal Letters
More than 300 pulsars have been discovered in Galactic globular clusters; however, none have been found in open clusters. Here we present results from a 20 hr survey of seven open clusters with the Five-hundred-meter Aperture Spherical radio Telescope ...
Xiao-Jin Liu, Rahul Sengar, Matthew Bailes, Ralph P. Eatough, Jianping Yuan, Na Wang, Weiwei Zhu, Lu Zhou, He Gao, Zong-Hong Zhu, Xing-Jiang Zhu   +10 more
doaj   +1 more source