Results 161 to 170 of about 976,493 (346)

Cancer cell death induced by the NAD antimetabolite Vacor discloses the antitumor potential of SARM1

open access: yesFEBS Letters, EarlyView.
Vacor, a compound converted into the toxic metabolite Vacor adenine dinucleotide (VAD) by the nicotinamide salvage pathway enzymes NAMPT and NMNAT2, exhibits antitumor activity by inducing rapid and complete NAD depletion. We report that Vacor toxicity is limited to cell lines expressing high levels of SARM1, a NAD glycohydrolase.
Giuseppe Ranieri   +5 more
wiley   +1 more source

Dynamics of Star Cluster Formation: The Effects of Ongoing Star Formation and Stellar Feedback

open access: yesThe Astrophysical Journal
We perform a high-resolution zoomed-in simulation of star cluster assembly including the merger of two subclusters with initial conditions taken from previous large-scale giant molecular cloud (GMC) simulations.
Jeremy Karam   +2 more
doaj   +1 more source

Protein kinase FAM20C—when subcellular localization matters

open access: yesFEBS Letters, EarlyView.
FAM20C is a Golgi‐resident kinase that phosphorylates proteins along the entire secretory pathway. The presence of potential FAM20C substrates in the cytoplasm or nucleus raises the question of how the kinase and its substrates encounter each other. Protein kinases achieve signaling specificity through consensus sequence recognition and subcellular ...
Francesca Noventa, Mauro Salvi
wiley   +1 more source

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

open access: yesFEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

Alignment Parameters: Quantifying Dense Core Alignment in Star-forming Regions

open access: yesThe Astrophysical Journal
Recent high-resolution observations at millimeter (mm) and submillimeter wavelengths reveal a diverse spatial distribution for subparsec-scale dense cores within star-forming regions, ranging from clustered to aligned arrangements.
Wei-An Chen   +3 more
doaj   +1 more source

RAD50 missense variants differentially affect the DNA damage response and mitotic progression

open access: yesFEBS Letters, EarlyView.
RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker   +9 more
wiley   +1 more source

Pulling Back the Curtain on Shocks and Star Formation in NGC 1266 with Gemini-NIFS

open access: yesThe Astrophysical Journal
We present Gemini near-infrared integral field spectrograph K -band observations of the central 400 pc of NGC 1266, a nearby ( D ≈ 30 Mpc) post-starburst galaxy with a powerful multiphase outflow and a shocked interstellar medium.
Justin Atsushi Otter   +23 more
doaj   +1 more source

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