Berkeley 87, a heavily-obscured young cluster associated with the ON2 star-formation complex and containing the WO star Stephenson 3 [PDF]
D. G. Turner, D. Forbes
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Cancer cell death induced by the NAD antimetabolite Vacor discloses the antitumor potential of SARM1
Vacor, a compound converted into the toxic metabolite Vacor adenine dinucleotide (VAD) by the nicotinamide salvage pathway enzymes NAMPT and NMNAT2, exhibits antitumor activity by inducing rapid and complete NAD depletion. We report that Vacor toxicity is limited to cell lines expressing high levels of SARM1, a NAD glycohydrolase.
Giuseppe Ranieri+5 more
wiley +1 more source
Dynamics of Star Cluster Formation: The Effects of Ongoing Star Formation and Stellar Feedback
We perform a high-resolution zoomed-in simulation of star cluster assembly including the merger of two subclusters with initial conditions taken from previous large-scale giant molecular cloud (GMC) simulations.
Jeremy Karam+2 more
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Protein kinase FAM20C—when subcellular localization matters
FAM20C is a Golgi‐resident kinase that phosphorylates proteins along the entire secretory pathway. The presence of potential FAM20C substrates in the cytoplasm or nucleus raises the question of how the kinase and its substrates encounter each other. Protein kinases achieve signaling specificity through consensus sequence recognition and subcellular ...
Francesca Noventa, Mauro Salvi
wiley +1 more source
Some Observational Evidence for Isolated Star Formation and a Possible Interpretation
Philip C. Steffey
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Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley +1 more source
Alignment Parameters: Quantifying Dense Core Alignment in Star-forming Regions
Recent high-resolution observations at millimeter (mm) and submillimeter wavelengths reveal a diverse spatial distribution for subparsec-scale dense cores within star-forming regions, ranging from clustered to aligned arrangements.
Wei-An Chen+3 more
doaj +1 more source
Star Formation in Interstellar Clouds: Studies with a Modified Virial Theorem
Thomas T. Arny
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RAD50 missense variants differentially affect the DNA damage response and mitotic progression
RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker+9 more
wiley +1 more source
Pulling Back the Curtain on Shocks and Star Formation in NGC 1266 with Gemini-NIFS
We present Gemini near-infrared integral field spectrograph K -band observations of the central 400 pc of NGC 1266, a nearby ( D ≈ 30 Mpc) post-starburst galaxy with a powerful multiphase outflow and a shocked interstellar medium.
Justin Atsushi Otter+23 more
doaj +1 more source