Results 181 to 190 of about 976,493 (346)

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

Metal-poor Star-forming Clumps in Cosmic Noon Galaxies: Evidence for Gas Inflow and Chemical Dilution Using JWST NIRISS

The Astrophysical Journal
The formation and evolution of galaxies are intricately linked to the baryon cycle, which fuels star formation while shaping chemical abundances within galaxies.
Vicente Estrada-Carpenter, Marcin Sawicki, Roberto Abraham, Yoshihisa Asada, Maruša Bradač, Gabe Brammer, Guillaume Desprez, Kartheik G. Iyer, Nicholas S. Martis, Adam Muzzin, Gaël Noirot, Gregor Rihtaršič, Ghassan T. E. Sarrouh, Chris J. Willott, Jeremy Favaro, Vladan Markov, Rosa M. Mérida, Katherine Myers, Visal Sok   +18 more
doaj   +1 more source

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

Molecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti, Manuel Scimeca, Julia Bischof, Jonathan Woodsmith, Massimiliano Agostini, Cristina Fiorani, Yufang Shi, Eleonora Candi, Gerry Melino, Alessandro Mauriello, Giuseppe S. Sica   +10 more
wiley   +1 more source

Exploring Lenticular Galaxy Formation in Field Environments Using NewHorizon: Evidence for Counterrotating Gas Accretion as a Formation Channel

The Astrophysical Journal
The formation pathways of lenticular galaxies (S0s) in field environments remain a matter of debate. We utilize the cosmological hydrodynamic simulation, NewHorizon , to investigate the issue. We select two massive star formation quenched S0s as our main
Seongbong Han, J. K. Jang, Emanuele Contini, Yohan Dubois, Seyoung Jeon, Sugata Kaviraj, Taysun Kimm, Katarina Kraljic, Sree Oh, Sébastien Peirani, Christophe Pichon, Sukyoung K. Yi   +11 more
doaj   +1 more source

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

A Census of Star Formation in the Outer Galaxy: The SMOG Field. [PDF]

Astrophys J, 2019
Winston E, Hora J, Gutermuth R, Tolls V.
europepmc   +1 more source

Star Formation in Molecular Cloud Cores [PDF]

, 1987
Frank H. Shu, Susana Lizano, Fred C. Adams   +2 more
openalex   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

Fast and inefficient star formation due to short-lived molecular clouds and rapid feedback. [PDF]

Nature, 2019
Kruijssen JMD, Schruba A, Chevance M, Longmore SN, Hygate APS, Haydon DT, McLeod AF, Dalcanton JJ, Tacconi LJ, van Dishoeck EF.   +9 more
europepmc   +1 more source

The energetics and mass structure of regions of star formation: S201 [PDF]

, 1984
H. A. Thronson, H. A. Smith, C. J. Lada, W. Glaccum, D. A. Harper, R. F. Loewenstein, J. D. Smith   +6 more
openalex   +1 more source