Results 131 to 140 of about 318,054 (345)

C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules

FEBS Letters, EarlyView.
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican, Yara Nabawi, William Hongyu Zhang, Dunja Petrovic, Markus Wehrmann, Sara Muñoz‐García, Seda Koyuncu, David Vilchez   +7 more
wiley   +1 more source

VLA 22 GHz Imaging of Massive Star Formation in Local Wolf–Rayet Galaxies

The Astrophysical Journal
We present 22 GHz imaging of regions of massive star formation within the Local Wolf–Rayet Galaxy Sample, a NSF Karl G. Jansky Very Large Array survey of 30 local galaxies showing spectral features of Wolf–Rayet (WR) stars.
Nicholas G. Ferraro, Jean L. Turner, Sara C. Beck, Edwin Alexani, Runa Indrei, Bethany M. Welch, Tunhui Xie   +6 more
doaj   +1 more source

Are There Age Spreads in Star Forming Regions? [PDF]

, 2011
To appear in the proceedings of JENAM10: Star Clusters in the Era of Large Surveys, 8 ...
openaire   +3 more sources

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source

Near Infrared Polarimetry of Dark Clouds and Star Forming Regions - Two Micron Polarization Survey of T Tauri Stars [PDF]

, 1990
Motohide Tamura, S. Sato
openalex   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Investigating the Star-forming Sites in the Outer Galactic Arm

The Astronomical Journal
We aim to investigate the global star formation scenario in star-forming sites AFGL 5157, [FSR2007] 0807 (hereafter FSR0807), [HKS2019] E70 (hereafter E70), [KPS2012] MWSC 0620 (hereafter KPS0620), and IRAS 05331+3115 in the outer Galactic arm.
Aayushi Verma, Saurabh Sharma, Lokesh K. Dewangan, Devendra K. Ojha, Kshitiz Mallick, Ram Kesh Yadav, Harmeen Kaur, Tarak Chand, Mamta, Archana Gupta   +9 more
doaj   +1 more source

SiO in Star Forming Regions: Barnard 1 and Orion KL [PDF]

, 1994
Satoshi Yamamoto, Hitomi Mikami, Shuji Saito   +2 more
openalex   +1 more source

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

Molecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti, Manuel Scimeca, Julia Bischof, Jonathan Woodsmith, Massimiliano Agostini, Cristina Fiorani, Yufang Shi, Eleonora Candi, Gerry Melino, Alessandro Mauriello, Giuseppe S. Sica   +10 more
wiley   +1 more source

Magnetic Field Alignment Relative to Multiple Tracers in the High-mass Star-forming Region RCW 36

The Astrophysical Journal
We use polarization data from SOFIA HAWC+ to investigate the interplay between magnetic fields and stellar feedback in altering gas dynamics within the high-mass star-forming region RCW 36, located in Vela C.
Akanksha Bij, Laura M. Fissel, Lars Bonne, Nicola Schneider, Marc Berthoud, Dennis Lee, Giles A. Novak, Sarah I. Sadavoy, Thushara G. S. Pillai, Maria Cunningham, Paul Jones, Robert Simon   +11 more
doaj   +1 more source