Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Space Situational Awareness in Very Low Earth Orbit for Re-Entry Object Monitoring
AerospaceAs the number of objects in orbit increases every year, the number of objects re-entering Earth’s atmosphere grows as well. Re-entry path prediction is tricky, as atmospheric modeling lacks accuracy and requires constant monitoring of the object during ...
Ruth Huang +4 more
doaj +1 more source
Experimental investigation of an attitude control system that uses star trackers and inertia wheels [PDF]
, 1970 Simulation tests of attitude control system that uses star trackers and inertia ...
Dishman, B. H., Showman, R. D.
core
Localized distortion estimation and correction for the ICESat star trackers
, 2006 ICESat attitude determination is based on sensor data from three star trackers and a hemispherical resonator gyro. Methods for estimating and correcting star tracker distortion using on-orbit data are studied here.
Smith, Noah Harold
core +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
The STAR Heavy Flavor Tracker (HFT).
, 2014 Contribution to ...
Schambach, Joachim +11 more
openaire +3 more sources
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Optimization of star research algorithm for esmo star tracker [PDF]
, 2011 This paper explains in detail the design and the development of a software research star algorithm, embedded on a star tracker, by the ISAE/SUPAERO team. This research algorithm is inspired by musical techniques.
Fabacher, Emilien +5 more
core
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source