Results 71 to 80 of about 583,316 (279)

On-Orbit Resident Space Object (RSO) Detection Using Commercial Grade Star Trackers [PDF]

, 2019
The resident space object (RSO) population, including both functioning satellites and on-orbit debris, has grown to the point where dedicated ground and space-based networks are needed to maintain up-to-date catalogues of their orbits.
Clemens, Samuel David
core  

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source

Optical-Algorithm Co-Design of a Lightweight Petzval Star Tracker with Selective Asymmetric Aberration Suppression

Remote Sensing
Traditional high-precision star trackers rely on long-focal-length optical configurations, which suffer from bulky volume and heavy weight, which restricts their application to small satellite platforms.
Haijun Wang, Hongjian Yu, Xuedi Chen, Qun Hao, Yao Meng, Ting Sun, Haifeng Yao, Fei Xing, Xinyuan Liu, Kaihua Qi   +9 more
doaj   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

Resident Space Object (RSO) Tracking in Space-Based, Low Resolution, Non-Constant-Attitude Imagery

Remote Sensing
Resident Space Objects (RSOs) are a collection of both man-made and natural objects in near-Earth space. Given their large orbital velocities and rapidly increasing quantity, they pose a collision threat to space assets, necessitating better Space ...
Perushan Kunalakantha, Vithurshan Suthakar, Paul Harrison, Matthew Driedger, Randa Qashoa, Gabriel Chianelli, Regina S. K. Lee   +6 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Debris Detection Using Star Tracker Concept Verification [PDF]

This paper demonstrates the concept of space debris detection using star trackers. Arcsec’s Sagitta star tracker is an optical sensor designed to determine spacecraft attitude based on captured star images. The Sagitta star tracker processes these images
Vandoren, Bram, Vandenberghe, Alexander, Kazemi, Laila, Delabie, Tjorven, Samson, Mikel   +4 more
core   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Technology Demonstration of Space Situational Awareness (SSA) Mission on Stratospheric Balloon Platform

Remote Sensing
As the number of resident space objects (RSOs) orbiting Earth increases, the risk of collision increases, and mitigating this risk requires the detection, identification, characterization, and tracking of as many RSOs as possible in view at any given ...
Randa Qashoa, Vithurshan Suthakar, Gabriel Chianelli, Perushan Kunalakantha, Regina S. K. Lee   +4 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source