Results 11 to 20 of about 4,861,089 (141)

Stargardt’s Disease: Molecular Pathogenesis and Current Therapeutic Landscape [PDF]

Int J Mol Sci
Stargardt’s disease (STGD1) is an autosomal recessive juvenile macular degeneration caused by mutations in the ABCA4 gene, impairing clearance of toxic retinoid byproducts in the retinal pigment epithelium (RPE).
Dayma, Kunal, Upadhyay, Arun, Arun Upadhyay, Kalpana Rajanala, Kunal Dayma, Rajanala, Kalpana   +5 more
core   +2 more sources

Nodular Scleritis with Stargardt’s Disease: A Rare Case Report

MAMC Journal of Medical Sciences, 2017
A 30-year-old female presented with recurrent red, painful right eye. Ocular examination revealed nodular scleritis and on complete workup, tuberculosis was found to be the causative agent.
Anubhav Chauhan, Lalit Gupta
doaj   +2 more sources

Subretinal Fibrosis in Stargardt’s Disease with Fundus Flavimaculatus and ABCA4 Gene Mutation

Case Reports in Ophthalmology, 2012
Purpose: To report on 4 patients affected by Stargardt’s disease (STGD) with fundus flavimaculatus (FFM) and ABCA4 gene mutation associated with subretinal fibrosis. Methods: Four patients with a diagnosis of STGD were clinically examined.
Settimio Rossi, Francesco Testa, Marcella Attanasio, Ada Orrico, Antonella de Benedictis, Michele Della Corte, Francesca Simonelli   +6 more
doaj   +2 more sources

Penetration, distribution, and elimination of remofuscin/soraprazan in Stargardt mouse eyes following a single intravitreal injection using pharmacokinetics and transmission electron microscopic autoradiography: Implication for the local treatment of Stargardt’s disease and dry age‐related macular degeneration [PDF]

Pharmacology Research & Perspectives, 2020
Age‐related macular degeneration (AMD) is the leading cause of blindness in older people in the developed world while Stargardt's disease (SD) is a juvenile macular degeneration and an orphan disease.
Sylvie Julien‐Schraermeyer, Barbara Illing, Alexander Tschulakow, Tatjana Taubitz, Jamil Guezguez, Michael Burnet, Ulrich Schraermeyer   +6 more
doaj   +2 more sources

Stargardt’s Connected Research Network Inaugural Meeting: Landscape Review and Horizon Scanning of Stargardt Disease [PDF]

Transl Vis Sci Technol
Purpose: The purpose of this study was to update the recent progress in the diagnosis, management, and treatments for Stargardt disease. Methods: On November 22, 2024, Stargardt’s Connected held its inaugural meeting of their Research Network, attended ...
Rozanowska, MB, Khan, S, Rizzi, M, Piccolo, D, Crossland, MD, Mendes, BS, Sumodhee, D, Tailor, B, de Guimaraes, TAC, Michaelides, M, Varela, MD, Girach, A, Skilton, A, Brandão, ML, Downes, SM, Woof, WA, Britten-Jones, AC, Cheetham, ME, Pontikos, N, Al-Khuzaei, S, Ayton, LN, Scholl, HPN   +21 more
core   +2 more sources

Perimetry of the Central Visual Field Using a Head-Mounted Open-Source Perimeter in Patients with Inherited Retinal Diseases [PDF]

Vision
Head-mounted (“virtual reality”) perimeters (HMPs), based on standard consumer electronic hardware, are a cheaper alternative to standard automated perimetry. They have not been validated in patients with inherited retinal disease (IRDs), yet.
Cord Huchzermeyer, Friedrich Kruse, Jan Kremers   +2 more
doaj   +2 more sources

Generation and characterization of a Stargardt’s disease-specific induced pluripotent stem cell line (LVPEIi008-A) with a homozygous nonsense mutation in exon 44 of ABCA4

Stem Cell Research
The Stargardt’s Disease, Type 1 (STGD1) is associated with the loss of function mutations in ABCA4. This gene codes for a retina-specific, ATP-binding cassette (ABC) family transporter, involved in the transport of the key visual cycle intermediate, all ...
Divya Pidishetty, Savitri Maddileti, Sudipta Mahato, Trupti Agrawal, Milind Naik, Chitra Kannabiran, Subhadra Jalali, Indumathi Mariappan   +7 more
doaj   +2 more sources

Stem cell therapy as treatment for Stargardt disease [PDF]

Therapeutic Advances in Ophthalmology
Stargardt disease or Juvenile Macular Degeneration is a rare genetic disorder caused by a mutation in the ABCA4 gene that results in degeneration of the macula and loss of central vision.
Erica Marks, Adith Anugu, Joseph Bisiani, Srinivas Pentyala   +3 more
doaj   +2 more sources

Texas Preventable Disease News [PDF]

, 1989
Newsletter of the Texas Bureau of Disease Control and Epidemiology discussing the news, activities, and events of the organization and other information related to health in ...
Texas. Bureau of Disease Control and Epidemiology.
core   +15 more sources

Exploring Stem-Cell-Based Therapies for Retinal Regeneration [PDF]

Life
The escalating prevalence of retinal diseases—notably, age-related macular degeneration and hereditary retinal disorders—poses an intimidating challenge to ophthalmic medicine, often culminating in irreversible vision loss. Current treatments are limited
Madalina Radu, Daniel Constantin Brănișteanu, Ruxandra Angela Pirvulescu, Otilia Maria Dumitrescu, Mihai Alexandru Ionescu, Mihail Zemba   +5 more
doaj   +2 more sources