Results 31 to 40 of about 4,861,089 (141)

The Safety and Efficacy of Stem Cell Therapies in the treatment of Macular Degeneration and Stargardt’s Macular Dystrophy [PDF]

, 2020
Introduction: Age related macular degeneration (AMD) and Stargardt’s macular dystrophy are conditions which affect the retinal pigment epithelium eventually leading to photoreceptor death and central vision loss.
Starovoitova, Lina
core   +1 more source

Mapping of the rod photoreceptor ABC transporter (ABCR) to 1p21–p22.1 and identification of novel mutations in Stargardt’s disease

, 1998
Using a bovine rod photoreceptor cell-specific ATP-binding cassette (ABC) transporter cDNA we have cloned the full-length transcript of the homologous human gene and demonstrate that it is identical to the photoreceptor cell-specific ABC transporter ...
Weber, Bernhard H. F., Molday, R. S., Nasonkin, I., Illing, M., Koehler, M. R., Schmid, M.   +5 more
core   +1 more source

Host genetic and epigenetic factors in toxoplasmosis

Memorias do Instituto Oswaldo Cruz, 2009
Analysing human genetic variation provides a powerful tool in understanding risk factors for disease. Toxoplasma gondii acquired by the mother can be transmitted to the fetus.
Sarra E Jamieson, Heather Cordell, Eskild Petersen, Rima McLeod, Ruth E Gilbert, Jenefer M Blackwell   +5 more
doaj   +1 more source

Choroidal hyper-reflective foci and vascularity in retinal dystrophy

Indian Journal of Ophthalmology, 2020
Purpose: To investigate choroidal hyper-reflective foci (HRF) in subjects with retinal dystrophy [Stargardt's disease (SGD) and retinitis pigmentosa (RP)] and their association with demographics, visual acuity, choroidal thickness (CT), and choroidal ...
Daren Hanumunthadu, Mohammed Abdul Rasheed, Abhilash Goud, Arushi Gupta, Kiran Kumar Vupparaboina, Jay Chhablani   +5 more
doaj   +1 more source

Nonparametric Regression for Cost‐Effectiveness Analyses With Observational Data—A Tutorial

Health Economics, EarlyView.
ABSTRACT Healthcare decision‐making often requires selecting among multiple treatment options under budget constraints, particularly when one option is more effective but also more costly. Cost‐effectiveness analysis (CEA) provides a framework for evaluating whether the health benefits of a treatment justify its additional costs.
Jonas Esser, Mateus Maia, Judith E. Bosmans, Johanna Maria van Dongen   +3 more
wiley   +1 more source

Implementation of experimental cellular (cellular-genetic) therapies on the example of eye diseases

Journal of Education, Health and Sport, 2020
The development of technology and a modern research approach in the 21st century has enabled access to new therapies in many fields of medicine and nanotechnology.
Patrycja Kapczuk, Karolina Rogulska, Anna Stangret, Agata Mularczyk, Angelika Szczęśniak, Katarzyna Topczewska, Konrad Grzeszczak   +6 more
doaj   +1 more source

Prime editing in neuropsychiatric disorders: From mutation‐specific target selection to clinical translation

Neuroprotection, EarlyView.
Abstract Prime editing, a novel clustered regularly interspaced short palindromic repeats (CRISPR)‐based technology, fuses a reverse transcriptase (RT) to an engineered CRISPR‐associated protein 9 (Cas9) and uses a prime editing guide RNA (pegRNA)‐encoded template.
Tianshan Ji, Yuan Zhang, Jinyi Zhao, Yiping Lu, Chengkun Wang   +4 more
wiley   +1 more source

Retinal Fundus Image Analysis for Diagnosis of Glaucoma: A Comprehensive Survey

IEEE Access, 2016
The rapid development of digital imaging and computer vision has increased the potential of using the image processing technologies in ophthalmology.
M. Caroline Viola Stella Mary, Elijah Blessing Rajsingh, Ganesh R. Naik   +2 more
doaj   +1 more source

The optical coherence tomography and microperimetry biomarker evaluation in patients with geographic atrophy (OMEGA) study: Geographic atrophy progression in fundus autofluorescence ‐ OMEGA report 3

Acta Ophthalmologica, EarlyView.
Abstract Purpose To measure the progression of geographic atrophy (GA) in subjects with age‐related macular degeneration (AMD) in a natural history study. Methods We analysed fundus autofluorescence (FAF) images using a semiautomatic method (RegionFinder) to quantify the GA area in a monocentric study.
Philippe Valmaggia, Georg Ansari, Nadja Inglin, Nils Schärer, Hanna Zuche, Chrysoula Gabrani, Faady Yahya, Marco Cattaneo, Kristina Pfau, Andrea Giani, Marieh Esmaeelpour, Taffeta Chingning Yamaguchi, Christian Prünte, Hendrik P. N. Scholl, Nicolas Feltgen, Leopold Schmetterer, Maximilian Pfau, Peter M. Maloca   +17 more
wiley   +1 more source

The impacts of high refractive errors on self‐reported visual function and visual concern

Acta Ophthalmologica, EarlyView.
Abstract Purpose To examine the association between refractive errors and self‐reported visual function and visual concern, considering self‐perceived present eyesight, concerns about vision, accomplishing less and limitations in daily activities in an eye‐healthy cohort.
Jens Riis Møller, Arevak Saruhanian, Jens Rovelt, Josefine Freiberg, Marcel Reimann, Jeppe Nygård Samuelsen, Christina Eckmann‐Hansen, Miriam Kolko, Nina Jacobsen, FOREVER Consortium   +9 more
wiley   +1 more source