Results 21 to 30 of about 122 (91)

Systematic identification of regulatory variants associated with cancer risk

Genome Biology, 2017
Background Most cancer risk-associated single nucleotide polymorphisms (SNPs) identified by genome-wide association studies (GWAS) are noncoding and it is challenging to assess their functional impacts.
Song Liu, Yuwen Liu, Qin Zhang, Jiayu Wu, Junbo Liang, Shan Yu, Gong-Hong Wei, Kevin P. White, Xiaoyue Wang   +8 more
doaj   +1 more source

Plant cis‐regulatory grammar: Decoding the multidimensional code of transcriptional regulation for programmable crop engineering

Journal of Integrative Plant Biology, EarlyView.
This review decodes the grammar of plant cis‐regulatory elements, revealing that their function emerges from sequence, chromatin accessibility, 3D topology, and cell type context. It highlights how single‐cell omics, CRISPR dissection, and AI‐driven design converge to enable predictive engineering and crop improvement. ABSTRACT Cis‐regulatory elements (
Libin Zhang, Maoteng Li
wiley   +1 more source

Genome‐wide association study of morphometric and metabolic characteristics in European populations of the sugar kelp Saccharina latissima

Journal of Phycology, EarlyView.
Abstract The sugar kelp Saccharina latissima is a promising candidate for sustainable aquaculture in the North Atlantic and Northeast Pacific, but genetic improvement has been hindered by a limited understanding of the genetic basis of economically important traits.
Stéphane Mauger, Komlan Avia, Lucie Jaugeon, Paolo Ruggeri, Zofia Nehr, Ousseini Issaka Salia, Jérôme Coudret, Emilie Gouhier, Aurélien Baud, Stéphane Loisel, Antoine Fort, Ronan Sulpice, Christophe Destombe, Philippe Potin, J. Mark Cock, Myriam Valero   +15 more
wiley   +1 more source

From Public to Private Governance, and Back—Eco‐Modulation as De‐Privatization in Extended Producer Responsibility (EPR)

Regulation &Governance, EarlyView.
ABSTRACT The European Union is advancing circular economy policies, aimed at reducing the environmental impacts of products across their life‐cycles. Extended Producer Responsibility (EPR) exemplifies this strategy. It privatizes the end‐of‐life management of products to their producers, seeking thereby to incentivize the producer to design ...
Harri Kalimo, Antti Jukka, Reid Lifset, Petrus Kautto   +3 more
wiley   +1 more source

MCP‐1 From Aging Dermal Adipose Tissue Impairs Hair Follicle Cycling via Macrophage Recruitment: Implications for Age‐Related Alopecia

Aging Cell, Volume 25, Issue 11, November 2026.
Aging orchestrates a dWAT–MCP‐1–CCR2 axis that recruits and reprograms macrophage subpopulations, disrupting the local M1/M2 balance and suppressing WNT signaling, thereby impairing both hair cycle transition and production of genes associated with melanogenesis.
Jian Chen, Yuhui Hou, Ke Ye, Yilong Guo, Pingping Sun, Fangfang Qi, Zhexiang Fan, Damao Dai, Xiaomin Liu, Shulian Wu, Demengjie Le, Zhiqi Hu, Yong Miao, Qian Qu   +13 more
wiley   +1 more source

Brain Transcriptomic Changes Associated With the Socially Regulated Behavioural Specialisation of Ant Queens

Molecular Ecology, Volume 35, Issue 21, November 2026.
ABSTRACT Insect societies are characterised by a reproductive division of labour between queens that monopolise egg production and workers that perform all non‐reproductive tasks. The queen specialisation in egg laying is typically considered to be constitutive and independent of environmental conditions, but this common assumption was recently ...
Hugo E. Le Lay, Maximilian F. Bolder, Thomas J. Colgan, Romain Libbrecht   +3 more
wiley   +1 more source

Diff-ATAC-STARR-Seq: A Method for Genome-Wide Functional Screening of Enhancer Activity in Vivo.

Biological & pharmaceutical bulletin, 2022
Transcriptional regulatory elements, including promoters and enhancers, play a key role in the cell-type specific regulation of the transcriptome. Application of rapidly evolving genetic tools, such as optogenetic/chemogenetic actuators and fluorescent reporters to elucidate the function of cell subtypes in vivo necessitates cell-type specific ...
Nagayasu, Kazuki, Andoh, Chihiro, Shirakawa, Hisashi, Kaneko, Shuji   +3 more
openaire   +2 more sources

Distribution of Big Tau Isoforms in the Human Central and Peripheral Nervous System

Annals of Neurology, Volume 100, Issue 4, Page 709-736, October 2026.
Objective Tau is widely studied in neurodegeneration, yet most work has focused on canonical brain tau isoforms. A longer isoform, “big tau,” produced by inclusion of exon 4a, is expressed in the peripheral nervous system (PNS) and central nervous system (CNS) regions.
Rama Krishna Koppisetti, Nicolas R. Barthélemy, Kanta Horie, Cindy V. Ly, Kaleigh F. Roberts, Srinivas Koutarapu, Richard J. Perrin, Erin E. Franklin, Chiara Pedicone, Joshua Orrick, Justin Melendez, Timothy M. Miller, Chihiro Sato, Nupur Ghoshal, Alison M. Goate, Celeste M. Karch, Randall J. Bateman, Soumya Mukherjee   +17 more
wiley   +1 more source

Comprehensive evaluation of diverse massively parallel reporter assays to functionally characterize human enhancers genome-wide

Genome Biology
Background Massively parallel reporter assays (MPRAs) and self-transcribing active regulatory region sequencing (STARR-seq) have revolutionized enhancer characterization by enabling high-throughput functional assessment of regulatory sequences.
Junke Zhang, Alden King-Yung Leung, Yutong Zhu, Li Yao, Avery Willis, Xiuqi Pan, Abdullah Ozer, Zhou Zhou, Keith Siklenka, Alejandro Barrera, Jin Liang, Nathaniel D. Tippens, Timothy E. Reddy, John T. Lis, Haiyuan Yu   +14 more
doaj   +1 more source

TargetGAN: A generative AI framework for the design of plant core promoters with targeted activity

Plant Communications
Plant core promoters (PCPs) are key genetic elements that control gene expression and have significant value for crop breeding and plant synthetic biology.
Xianglei Xiang, Qi Yao, Kaixuan Deng, Yuanxin Ge, Qi Xiong, Yuming Lu, Xuehai Hu   +6 more
doaj   +1 more source