Results 41 to 50 of about 122 (91)

An antiviral jacalin‐like lectin gene contributes to nonhost resistance and host determination of potexviruses among Brassicaceae

New Phytologist, Volume 250, Issue 5, Page 3283-3298, June 2026.
Summary Plant resistance influences the host range of pathogens; however, the mechanism driving this influence remains poorly understood. Brassicaceae species are not natural hosts of potexviruses, for reasons that have not yet been determined. This study investigated the molecular basis of nonhost resistance (NHR) to potexviruses in the Brassicaceae ...
Takumi Suzuki, Kazuya Ishikawa, Akira Yusa, Nozomu Iwabuchi, Kan Kimura, Tetsuya Yoshida, Mari Ota, Masato Suzuki, Masanobu Nishikawa, Kensaku Maejima, Shigetou Namba, Yasuyuki Yamaji   +11 more
wiley   +1 more source

Supremacy Rule of Law in the Service of a Depoliticised Democracy—Pondering the Nature of the EU's ‘Social Contract’

European Law Journal, Volume 32, Issue 1, Page 144-161, April 2026.
ABSTRACT Seeing the EU roughly as a political system designed to remove the most essential political decisions from democratic control, while in a large part abiding by legal frameworks, we could speak about an opposition between technocratic legalism and democracy.
Dimitry V. Kochenov, Jacquelyn D. Veraldi   +1 more
wiley   +1 more source

From Natural Discovery to AI‐Guided Design: A Curated Collection of Compact Enhancers for Crop Engineering

Advanced Science, Volume 13, Issue 13, 3 March 2026.
This study establishes an integrated platform combining high‐throughput screening (STEM‐seq) and AI‐guided design (BaseSearch) to develop compact transcriptional enhancers in crops. We identified thousands of functional short enhancers (60–80 bp) across four species, with the strongest showing 46.3‐fold activation.
Qi Yao, Jin Gao, Keling Wang, Yufeng Liu, Peijin Han, Hong Pan, Xiaofeng Yang, Qianlan Yin, Dating Zhong, Lu Ye, Qi Deng, Lingling Gao, Xiaoyu Tu, Dequan Wang, Yuming Lu   +14 more
wiley   +1 more source

Enhancer‐dependent gene regulation in space, time, and malignancies

International Journal of Cancer, Volume 158, Issue 2, Page 357-367, 15 January 2026.
Abstract Control of cell‐type‐specific gene activation requires the coordinated activity of distal regulatory elements, including enhancers, whose inputs must be temporally integrated. Dysregulation of this regulatory capacity, such as aberrant usage of enhancers, can result in malignant transformation of cells.
Belinda Blum, Victoria Dachtler, Angelika Feldmann   +2 more
wiley   +1 more source

A map of enhancer regions in primary human neural progenitor cells using capture STARR-seq

Genome Research
Genome-wide association studies (GWASs) and expression analyses implicate noncoding regulatory regions as harboring risk factors for psychiatric disease, but functional characterization of these regions remains limited. Here, we perform capture STARR-sequencing of over 70,000 candidate regions to identify active enhancers in primary human neural ...
Sophia C. Gaynor-Gillett, Lijun Cheng, Manman Shi, Jason Liu, Gaoyuan Wang, Megan Spector, Qiuyu Guo, Le Qi, Mary Flaherty, Martha Wall, Ahyeon Hwang, Mengting Gu, Zhanlin Chen, Yuhang Chen, Jennifer R. Moran, Jing Zhang, Donghoon Lee, Mark Gerstein, Daniel Geschwind, Kevin P. White   +19 more
openaire   +6 more sources

Additional file 2 of STARRPeaker: uniform processing and accurate identification of STARR-seq active regions

, 2020
Additional file 2: Supplementary Table S1. Peaks identified by STARRPeaker in each replicate and merged replicate from HepG2 and K562 cell lines.
Lee, Donghoon, Shi, Manman, Moran, Jennifer, Wall, Martha, Zhang, Jing, Liu, Jason, Fitzgerald, Dominic, Kyono, Yasuhiro, Ma, Lijia, White, Kevin P., Gerstein, Mark   +10 more
openaire   +1 more source

Integrative high-throughput enhancer surveying and functional verification divulges a YY2-condensed regulatory axis conferring risk for osteoporosis

Cell Genomics
Summary: The precise roles of chromatin organization at osteoporosis risk loci remain largely elusive. Here, we combined chromatin interaction conformation (Hi-C) profiling and self-transcribing active regulatory region sequencing (STARR-seq) to qualify ...
Xiao-Feng Chen, Yuan-Yuan Duan, Ying-Ying Jia, Qian-Hua Dong, Wei Shi, Yan Zhang, Shan-Shan Dong, Meng Li, Zhongbo Liu, Fei Chen, Xiao-Ting Huang, Ruo-Han Hao, Dong-Li Zhu, Rui-Hua Jing, Yan Guo, Tie-Lin Yang   +15 more
doaj   +1 more source

Deregulated enhancer‐promoter communication in cancer through altered nuclear architecture

International Journal of Cancer, Volume 158, Issue 2, Page 409-422, 15 January 2026.
Abstract Enhancers are critical regulators of gene expression. Structural variations in cancer genomes can lead to enhancer hijacking, where oncogenes are activated by mistargeted enhancer activity. Novel enhancer‐promoter interactions may also arise through chromosomal rearrangements that create extrachromosomal DNA elements.
Isabelle Seufert, Claire Vargas, Sina Jasmin Wille, Karsten Rippe   +3 more
wiley   +1 more source

Single-cell multiome and enhancer connectome of human retinal pigment epithelium and choroid nominate causal variants in macular degeneration

Cell Reports
Summary: Age-related macular degeneration (AMD) is a leading cause of vision loss worldwide. Genome-wide association studies (GWASs) of AMD have identified dozens of risk loci that may house disease targets.
Sean K. Wang, Jiaying Li, Surag Nair, Reshma Kosaraju, Yun Chen, Yuanyuan Zhang, Anshul Kundaje, Yuwen Liu, Ningli Wang, Howard Y. Chang   +9 more
doaj   +1 more source

KAS‐Seq Captures Global Transcription Dynamics and Active Single‐Stranded Enhancers in Rice

Plant Biotechnology Journal, Volume 24, Issue 9, Page 5010-5012, September 2026.
Haoxuan Li, Xuling Li, Kayla He, Hua Dang, Wei Shen, Pingxian Zhang, Chuan He, Guanqun Wang   +7 more
wiley   +1 more source