Results 31 to 40 of about 687 (217)
Probing the Interior of Neutron Stars with Gravitational Waves
Physical Review Letters, 2005 8 pages, 4 figures, 1 ...
Tsui, L. K., Leung, P. T.
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Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Superfluidity in the Interiors of Neutron Stars [PDF]
, 1989 I review some of the ideas that have been proposed for the structure of neutron star interiors, and concentrate on the theoretical arguments for the existence of superfluidity in neutron stars. I also discuss the implications of neutron superfluidity and proton superconductivity for the rotational dynamics of pulsars, and review arguments that have ...
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Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
PRISMA: A mission to study interior and surface of stars [PDF]
International Astronomical Union Colloquium, 1994 AbstractNew technics such as asteroseismology are able to sound the deep interior of stars and to provide the data that will constrain the modelisation of the core. This information will be combined with data collected from the stellar surface which give direct access to measurements of the radiative losses, angular momentum losses and distribution of ...
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TULIPS: A Tool for Understanding the Lives, Interiors, and Physics of Stars
Astronomy and Computing, 2022 Accepted for publication in Astronomy & Computing. Documentation for TULIPS can be found at https://astro-tulips.readthedocs.io/en/latest/ . The code is available at https://bitbucket.org/elaplace/tulips/src/master/
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Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Probe into the interior of compact stars
, 2007 The interior of neutron stars contains nuclear matter at very high density for numerous subatomic particles compete with each other. Therefore, confirming the components and properties there is our significant task. Here we summarize the possible methods especial the way of r-mode instability to probe into the neutron star and show our some results ...
Pan, Nana, Kang, Miao
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