Results 41 to 50 of about 1,798 (265)

Pressures Great and Small [PDF]

, 2020
The astroquarks delve into the interiors of White Dwarfs, the relics of sunlike stars, with the help of Einstein\u27s theory of general relativity. And the Mars Insight lander collected some intriguing data that may help pin down the details of the death
Colwell, Joshua, Cooney, James, Dove, Adrienne   +2 more
core  

Modelling transport processes in stellar interiors using asteroseismic data [PDF]

, 2016
In this contribution, the modelling of transport processes in stellar interiors is first presented. The impact of rotation, magnetic fields and internal gravity waves on the internal and global stellar properties are briefly described.
P. Eggenberger
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Interfaces in Numerical Relativistic hydrodynamics [PDF]

, 2010
This thesis investigates numerical techniques for modelling sharp interfacesbetween relativistic fluids. The motivation for this work lies in obtaining accuratemodels of neutron star interiors for use in multidimensional simulationsin general relativity.
Millmore, Stephen Timothy
core  

Surface magnetism of cool stars [PDF]

, 2016
Summary of the splinter session "Surface Magnetism of Cool Stars" at the Cool Stars 19 conference; to be published in Astronomische NachrichtenInternational audienceMagnetic fields are essential ingredients of many physical processes in the interiors ...
Fares, R.,, Folsom, C. P., Rosen, L., R. Fares, Jeffers, S. V.,, P. Petit, Carroll, T. A.,, Monnier, J. D., Petit, P., Kochukhov, Oleg, Roettenbacher, R. M., R. M. Roettenbacher, Rosén, Lisa,, D. Shulyak, Roettenbacher, Rachael M.,, L. Rosén, J. Morin, J. D. Monnier, Rosen, Julia L., Korhonen, H.,, C. P. Folsom, Korhonen, H., Morin, J., Kochukhov, Oleg,, Strassmeier, K. G., Jeffers, Sandra V., Fares, R., Shulyak, D., O. Kochukhov, S. V. Jeffers, Petit, P.,, H. Korhonen, Morin, Julien, Strassmeier, K. G.,, Monnier, J. D.,, K. G. Strassmeier, Carroll, T. A., Morin, J.,, Kochukhov, O., Monnier, J.D., Shulyak, D.,, Roettenbacher, R. M.,, Jeffers, S. V., Folsom, C. P.,, T. A. Carroll   +44 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Neutron Stars—Cooling and Transport [PDF]

, 2015
Observations of thermal radiation from neutron stars can potentially provide information about the states of supranuclear matter in the interiors of these stars with the aid of the theory of neutron-star thermal evolution.
Pons, José A., Page, Dany, Potekhin, Alexander Y.   +2 more
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Convection and differential rotation properties of G and K stars computed with the ASH code [PDF]

, 2011
International audienceThe stellar luminosity and depth of the convective envelope vary rapidly with mass for G-and K-type main sequence stars. In order to understand how these properties influence the convective turbulence, differential rotation, and ...
Brun, A.S., Olivier Do Cao, Matt1, S.P., Brown, B.P., Benjamin P. Brown, Do Cao, O., Allan Sacha Brun, S.P. Matt, Sean P. Matt, B.P. Brown, O. Do Cao, A.S. Brun   +11 more
core   +1 more source