Results 11 to 20 of about 1,741,412 (341)
JAK/STAT pathway: Extracellular signals, diseases, immunity, and therapeutic regimens
Frontiers in Bioengineering and Biotechnology, 2023 Janus kinase/signal transduction and transcription activation (JAK/STAT) pathways were originally thought to be intracellular signaling pathways that mediate cytokine signals in mammals.
Q. Hu +8 more
semanticscholar +1 more source
Molecular Biomedicine, 2023 The Janus kinase-signal transducer and transcription activator pathway (JAK-STAT) serves as a cornerstone in cellular signaling, regulating physiological and pathological processes such as inflammation and stress.
Alexey Sarapultsev +5 more
semanticscholar +1 more source
Lineage plasticity in prostate cancer depends on JAK/STAT inflammatory signaling
Science, 2022 Drug resistance in cancer is often linked to changes in tumor cell state or lineage, but the molecular mechanisms driving this plasticity remain unclear. Using murine organoid and genetically engineered mouse models, we investigated the causes of lineage
J. Chan +26 more
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The Role of JAK/STAT Pathway in Fibrotic Diseases: Molecular and Cellular Mechanisms
Biomolecules, 2023 There are four members of the JAK family and seven of the STAT family in mammals. The JAK/STAT molecular pathway could be activated by broad hormones, cytokines, growth factors, and more.
Jia Liu, Faping Wang, F. Luo
semanticscholar +1 more source
JAK–STAT signaling pathway in the pathogenesis of atopic dermatitis: An updated review
Frontiers in Immunology, 2022 Atopic dermatitis (AD) is a chronic, inflammatory, pruritic form of dermatosis with heterogeneous manifestations that can substantially affect patients' quality of life. AD has a complex pathogenesis, making treatment challenging for dermatologists.
I-Hsin Huang +3 more
semanticscholar +1 more source
Role of JAK/STAT in Interstitial Lung Diseases; Molecular and Cellular Mechanisms
International Journal of Molecular Sciences, 2021 Interstitial lung diseases (ILDs) comprise different fibrotic lung disorders characterized by cellular proliferation, interstitial inflammation, and fibrosis.
P. Montero +3 more
semanticscholar +1 more source
Nature Cancer, 2022 Emerging evidence indicates that various cancers can gain resistance to targeted therapies by acquiring lineage plasticity. Although various genomic and transcriptomic aberrations correlate with lineage plasticity, the molecular mechanisms enabling the ...
S. Deng +25 more
semanticscholar +1 more source
Cytokine & Growth Factor Reviews, 2007 The ability of transcription factors to gain entrance to the nucleus is critical to their role in gene expression. Signal transducers and activators of transcription (STATs) are latent DNA binding factors activated by specific tyrosine phosphorylation. There are seven mammalian STAT genes encoding proteins that display constitutive nuclear localization
openaire +2 more sources
JAK/STAT Signaling and Cervical Cancer: From the Cell Surface to the Nucleus
Genes, 2023 The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling pathway constitutes a rapid signaling module from the cell surface to the nucleus, and activates different cellular responses, such as proliferation, survival ...
Arturo Valle-Mendiola +2 more
semanticscholar +1 more source
Factoring Higher-Dimensional Shifts Of Finite Type Onto The Full Shift [PDF]
, 2005 A one-dimensional shift of finite type with entropy at least log factors onto the full -shift. The factor map is constructed by exploiting the fact that , or a subshift of , is conjugate to a shift of finite type in which every symbol can be followed by ...
Johnson, Aimee S.A., Madden, K.
core +2 more sources