Results 21 to 30 of about 1,741,412 (341)

JAK/STAT Signaling: Molecular Targets, Therapeutic Opportunities, and Limitations of Targeted Inhibitions in Solid Malignancies

open access: yesFrontiers in Pharmacology, 2022
JAK/STAT signaling pathway is one of the important regulatory signaling cascades for the myriad of cellular processes initiated by various types of ligands such as growth factors, hormones, and cytokines. The physiological processes regulated by JAK/STAT
B. Rah   +15 more
semanticscholar   +1 more source

A Single Point Mutation in the Mumps V Protein Alters Targeting of the Cellular STAT Pathways Resulting in Virus Attenuation

open access: yesViruses, 2019
Mumps virus (MuV) is a neurotropic non-segmented, negative-stranded, enveloped RNA virus in the Paramyxovirus family. The 15.4 kb genome encodes seven genes, including the V/P, which encodes, among other proteins, the V protein.
Tahir Malik   +3 more
doaj   +1 more source

Measurement of Branching Fraction and Dalitz Distribution for B0->D(*)+/- K0 pi-/+ Decays [PDF]

open access: yes, 2005
We present measurements of the branching fractions for the three-body decays B0 -> D(*)-/+ K0 pi^+/-$ and their resonant submodes $B0 -> D(*)-/+ K*+/- using a sample of approximately 88 million BBbar pairs collected by the BABAR detector at the PEP-II ...
A. A. Salnikov   +606 more
core   +4 more sources

The Oncogene AF1Q is Associated with WNT and STAT Signaling and Offers a Novel Independent Prognostic Marker in Patients with Resectable Esophageal Cancer

open access: yesCells, 2019
: AF1q impairs survival in hematologic and solid malignancies. AF1q expression is associated with tumor progression, migration, and chemoresistance, and acts as a transcriptional co-activator in WNT and STAT signaling.
Elisabeth S. Gruber   +10 more
doaj   +1 more source

Serology versus Real Time PCR in the Diagnosis of Human Brucellosis

open access: yesJournal of Pure and Applied Microbiology, 2017
With the unwelcome re-emergence of brucellosis in different regions of the world, an accurate and timely diagnosis of this zoonosis has become a daunting challenge.
Sara El-Hossain Aly Reda   +3 more
doaj   +1 more source

2-Thiopyrimidine/chalcone hybrids: design, synthesis, ADMET prediction, and anticancer evaluation as STAT3/STAT5a inhibitors

open access: yesJournal of Enzyme Inhibition and Medicinal Chemistry, 2020
A novel 2-thiopyrimidine/chalcone hybrid was designed, synthesised, and evaluated for their cytotoxic activities against three different cell lines, K-562, MCF-7, and HT-29. The most active cytotoxic derivatives were 9d, 9f, 9n, and 9p (IC50=0.77–1.74 µM,
Phoebe F. Lamie, John N. Philoppes
doaj   +1 more source

Effects Of Chemically Pretreated Bovine Serum Samples On Sensitivity Of Rose Bengal Test For Serodiagnosis Of Bovine Brucellosis

open access: yesJournal of Applied Veterinary Sciences, 2020
The standard serological test such as Rose Bengal Plate Test (RBPT) is routinely used for the diagnosis of brucellosis. This test depends on the agglutination of colored particulate antigen (killed Brucella organisms) by the antibodies present in sera ...
Lamees A. El-Tantawy   +3 more
doaj   +1 more source

JAK‐STAT core cancer pathway: An integrative cancer interactome analysis

open access: yesJournal of Cellular and Molecular Medicine, 2022
Through a comprehensive review and in silico analysis of reported data on STAT‐linked diseases, we analysed the communication pathways and interactome of the seven STATs in major cancer categories and proposed rational targeting approaches for ...
Fettah Erdogan   +10 more
semanticscholar   +1 more source

Beskyttelsesplikt over alle grenser?

open access: yesNorsk Statsvitenskapelig Tidsskrift, 2017
SAMMENDRAG Denne artikkelen diskuterer hva slags beskyttelsesplikt stater har overfor sine borgere, når de befinner seg utenfor statens grenser.
Halvard Leira
doaj   +1 more source

The Symbolic Dynamics Of Multidimensional Tiling Systems [PDF]

open access: yes, 2003
We prove a multidimensional version of the theorem that every shift of finite type has a power that can be realized as the same power of a tiling system.
Coven, E. M.   +3 more
core   +2 more sources

Home - About - Disclaimer - Privacy