Results 231 to 240 of about 4,584,115 (291)

African Swine Fever Virus pD345L Suppresses JAK-STAT Signaling by Selectively Triggering STAT1 Degradation. [PDF]

Int J Mol Sci
Gu Y, Gao M, Huang Y, Tao C, Wang Z, Xiao R, Jin X, Jia H, Yuan W.   +8 more
europepmc   +1 more source

Dedifferentiation in endometrial cancer is associated with HLA‐I silencing that may be restored by IFN‐γ

The Journal of Pathology, Volume 270, Issue 3, Page 317-327, November 2026.
Abstract Dedifferentiated endometrial carcinoma occurs when a prognostically favorable low‐grade endometrial carcinoma transforms into a highly aggressive undifferentiated carcinoma following genomic inactivation of core SWItch/Sucrose Non‐Fermentable (SWI/SNF) complex protein(s).
Antonio De Leo, Madison Wickenberg, Marco Grillini, Camelia Alexandra Coadǎ, Pooja Praveen Kumar, Annie Tong, James Key, Hannah Kim, Felix Kommoss, Mark Carey, Yangxin Fu, Claudio Ceccarelli, Giovanni Tallini, Paul LaPointe, Martin Köbel, Cheng‐Han Lee   +15 more
wiley   +1 more source

Wild-type C9orf72 drives proteasomal dysfunction and mutant aggregates via a Stat1-Isg15 axis in Huntington's disease. [PDF]

Neurotherapeutics
Chan SC, Tung CW, Chang CY, Su CC, Chen YC, Wu PM, Tung CY, Chen SF, Kuo HY, Cheng PH, Chen CM, Yang SH.   +11 more
europepmc   +1 more source

Klotho Deficiency Impairs Distal Potassium Homeostasis Through mTORC1‐Dependent Suppression of ROMK

Acta Physiologica, Volume 242, Issue 11, November 2026.
ABSTRACT Aim Hyperkalemia is prevalent in the elderly, and underlying molecular mechanisms remain incompletely understood. We hypothesized that Klotho deficiency, a feature of aging, impairs renal potassium homeostasis and contributes to hyperkalemia. Methods Klotho heterozygous knockout (KLhet) mice, characterized by reduced Klotho levels, were used ...
Wakako Kawarazaki, Nobuhiro Ayuzawa, Mitsuhiro Nishimoto, Daigoro Hirohama, Kohei Ueda, Takeshi Marumo, Toshiro Fujita   +6 more
wiley   +1 more source

An Increased Circular RNA, circRNPS1, in T Cells of Ankylosing Spondylitis Patients Enhances the MEK/ERK Signaling and Inflammation Mediated by T Cell Activation via Stabilization of hnRNPK and VAV1. [PDF]

Int J Mol Sci
Yu HC, Lai NS, Huang KY, Chen PC, Lu MC, Huang HB.   +5 more
europepmc   +1 more source

4‐1BBL Suppresses Anti‐Inflammatory Responses by Regulating Metabolic Reprogramming of Macrophages

Immunology, Volume 179, Issue 3, Page 434-443, November 2026.
4‐1BB ligand (4‐1BBL) is known to promote sustained pro‐inflammatory responses in macrophages. This study demonstrates that 4‐1BBL acts as a negative regulator of anti‐inflammatory macrophage responses. Genetic deletion or pharmacological inhibition of 4‐1BBL significantly enhanced the phosphorylation of IL‐4R‐proximal JAK1 and STAT6, elevating the ...
Young Jun Kang
wiley   +1 more source

Nuclear RSK1 mediates interferon-γ-induced proinflammatory activation in human primary macrophages and humanized mice. [PDF]

Sci Adv
Nihira K, Yanagihara Y, Nakamura Y, Chelvanambi S, Halu A, Lee LH, Mojcher A, Higashi H, Yamada I, Qiao J, Mlynarchik AK, Wang J, Decano JL, Aikawa E, Vrbanac V, Singh SA, Aikawa M.   +16 more
europepmc   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, Volume 20, Issue 10, Page 2510-2532, October 2026.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Multi‐Omics Profiling of High‐Grade Serous Ovarian Cancer Reveals an Inflammation‐Related Lipid Metabolism Subtype Associated With Platinum Resistance

Advanced Science, Volume 13, Issue 55, 5 October 2026.
Through integrated proteomic and metabolomic profiling, Zhao et al. identified three molecular subtypes of high‐grade serous ovarian cancer. The high‐risk subtype exhibits activated arachidonic acid metabolism and cyclooxygenase‐2 overexpression. This metabolic axis promotes M2‐like macrophage infiltration, which contributes to platinum resistance ...
Yuxi Zhao, Junyi Li, Bo Zheng, Wanshan Liu, Yaru Wang, Shufeng Wang, Ying Cui, Huiqin Guo, Hongxia Wang, Ting Xiao, Kun Qian, Jing Zuo   +11 more
wiley   +1 more source

Propionate promotes CD8⁺ T-cell infiltration and enhances immunotherapy efficacy in colorectal cancer. [PDF]

J Immunother Cancer
Pan J, Tong L, Fei R, Wu K, Ji J, Sun T, Zhao Y, Zhang J, Feng H, Hua H, Yao HP.   +10 more
europepmc   +1 more source