Results 231 to 240 of about 79,832 (300)

XIAP Deficiency Impairs Colonic Tuft Cell Development and Predisposes to Crohn's Disease

MedComm, Volume 7, Issue 5, May 2026.
XIAP deficiency leads to impaired colonic tuft cells development and JAK–‐STAT pathway hyperactivation in CD patients and mice. Mechanically, XIAP regulates tuft cells development through Wnt–‐TLE4/TCF–‐ASCL2 signaling. Tuft cells deficiency predisposes XIAP‑‐deficient CD patients or Xiap−/−‐/‐ mice to hazardous microbial effects, driving colonic ...
Rongli Fang, Wei Wang, Li Zhang, Jiwei Huang, Lei Huang, Huibo Wu, Yuyin Qi, Lili Li, Liren Tan, Min Zhang, Jianheng Zhu, Xiang Peng, Kanghua Zhong, Ming Zou, Xi Yang, Qiuhua Wang, Changjun Nie, Chaorui Tang, Ning Tang, Lanlan Geng, Hanhan Chen, James E. Vince, Hirokazu Kanegane, Xiaodong Zhao, Huifang Xian, Wenhao Zhou, Min Zhi, Yuxia Zhang, Zhanghua Chen   +28 more
wiley   +1 more source

RNA sequencing-derived gene co-expression and drug-gene interaction analysis reveal STAT1 as a potential therapeutic target in thrombotic antiphospholipid syndrome. [PDF]

Front Immunol
Baltsiotis M, Verrou KM, Sfikakis PP, Tektonidou MG.   +3 more
europepmc   +1 more source

Liver Fibrosis: Molecular Pathogenesis and Therapeutic Interventions

MedComm, Volume 7, Issue 5, May 2026.
We systematically summarized the etiologies, diagnostic approaches, and pathogenic mechanisms of liver fibrosis. Also, the therapeutic interventions for liver fibrosis were systematically classified into two main categories: etiological treatment and mechanism‐based antifibrotic therapies.
Jiaorong Qu, Wenqing Qin, Minghang Dong, Zhi Ma, Si Li, Runping Liu, Ranyun Chen, Changmeng Li, Xiaojiaoyang Li   +8 more
wiley   +1 more source

The JAK1-STAT1 signaling pathway triggers inflammation responses in chronic obstructive sleep apnea rat model. [PDF]

PLoS One
Yang L, He J.
europepmc   +1 more source

Maladaptive Inflammatory Signaling in Old Mice Impairs Colonic Regeneration by Promoting a Sustained Fetal‐Like Epithelial State

Aging Cell, Volume 25, Issue 5, May 2026.
This study explores the impact of aging on regeneration of the mouse colonic epithelium. The authors find that old mice exhibit excessive and prolonged inflammation after infection with Citrobacter, resulting in the maintenance of a fetal regenerative state in epithelial cells, insufficient tissue repair, and death of the animal.
Antonion Korcari, Helen Tauc, Jeff Duggan, Jina Yun, Fabien Wehbe, Spyros Darmanis, Zora Modrusan, Rajita Pappu, David Garfield, Heinrich Jasper, David Castillo‐Azofeifa   +10 more
wiley   +1 more source

METTL3-m⁶A-STAT1/NF-κB axis: a key switch for the immunosuppressive capacity of mesenchymal stem cells. [PDF]

Cell Mol Biol Lett
Tang K, Han H, Sun R, Xu Y, Zhang S, Lai C, Peng Y.   +6 more
europepmc   +1 more source

T Cell Immunosenescence in Inflammatory Skin Diseases: Pathogenesis and Therapeutic Targets

Aging Cell, Volume 25, Issue 5, May 2026.
Immunosenescent T cells promote inflammatory skin diseases such as psoriasis, atopic dermatitis, rosacea, and seborrheic dermatitis via hyperactive signaling networks and SASP secretion. Consequently, intercepting downstream SASP, inhibiting internal pathways, or utilizing senolytics represents promising therapeutic interventions.
Conghui Liu, Ming Yang, Fugang Xiao, Jinrong Zeng   +3 more
wiley   +1 more source

Bioinformatics analysis identifies candidate biomarkers associated with sarcoidosis. [PDF]

Sarcoidosis Vasc Diffuse Lung Dis
Jin L, Pan C, Sun Y, Zhang J, Xie W, He M.   +5 more
europepmc   +1 more source

STAT Signaling and Its Anti‐Apoptotic Effects in Dehydrated Xenopus laevis

Biology of the Cell, Volume 118, Issue 5, May 2026.
Dehydrated Xenopus laevis showed increased STAT3 and downstream anti‐apoptotic protein activation in the liver, whereas skeletal muscle saw increased STAT5 and downstream anti‐apoptotic protein activation, and decreased STAT1 activation. Collectively, these adaptations lead to decreased apoptosis, likely serving to protect against aestivation‐induced ...
Yulia Biggar, Akshay A. Kamath, Sarah A. Breedon, Kenneth B. Storey   +3 more
wiley   +1 more source