Results 241 to 250 of about 4,584,115 (291)

ApoE lipidation state directs immunometabolic reprogramming of human microglia

Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.
Abstract INTRODUCTION ApoE ε4 is the strongest genetic risk factor for Alzheimer's disease (AD). Emerging evidence suggests that ApoE4 increases AD risk by disrupting microglial metabolism and function. However, whether ApoE lipidation state contributes to microglial dysfunction remains poorly understood. METHODS Human microglia were treated with lipid‐
Tsion G. Shiferaw, Snigdha Sarkar, Katelyn M. Baker, Rowan S. Wooldridge, Hannah M. Binfet, Victoria N. Prozapas, Chinemerem P. Ogbu, Athena A. Schepmoes, Isaac K. Attah, Christy S. Niemeyer, Kayla G. Sprenger, James E. Hassell, Robert H. Eckel, John T. Melchior, Kimberley D. Bruce   +14 more
wiley   +1 more source

LUCAT1 drives arecoline-induced head and neck cancer progression via STAT1-mediated transcriptional regulation. [PDF]

Cell Mol Biol Lett
Huang HH, You GR, Chang JT, Cheng AJ.
europepmc   +1 more source

First‐in‐human, phase I, randomized, safety, pharmacokinetic, food‐effect and pharmacodynamic study of a tyrosine kinase 2/Janus kinase 1 inhibitor, SDC‐1801

British Journal of Clinical Pharmacology, Volume 92, Issue 10, Page 3513-3526, October 2026.
Aim The purpose of this study is to evaluate safety, tolerability, pharmacokinetics (PK), food‐effect (FE) and pharmacodynamics (PD) of an oral tyrosine kinase‐2 (TYK2)/Janus kinase‐1 (JAK1) inhibitor, SDC‐1801, in healthy adult participants. Methods This first‐in‐human study randomized 95 male and female participants.
Chris Brearley, Sam Francis, John Reader, Judi Proctor   +3 more
wiley   +1 more source

Fungal Infections in Disorders of Inborn Errors of Immunity. [PDF]

Clin Rev Allergy Immunol
Dhaliwal M, Thakur V, Warris A, Brown GD, Pilania RK, Dambuza IM.   +5 more
europepmc   +1 more source

Expression of COL6A1 in Tumor Matrix of Cholangiocarcinoma and Its Mechanism of Tumor Progression

Cancer Reports, Volume 9, Issue 10, October 2026.
ABSTRACT Background Cholangiocarcinoma (CCA), a malignant tumor originating from the bile duct epithelial cells, is characterized by aggressive invasion and poor prognosis. Abnormal remodeling of the tumor microenvironment plays a pivotal role in its disease progression.
Weibin Zhang, Chongshi Gao, Chongzhou Lan, Jia Dong, Boxing Xu, Yingmei Li, Jin Dai, Baitong Che, Cheng Li, Gang Dong, Yunfei Wu, Bo Li, Cheng Yang, Lingmei Kong   +13 more
wiley   +1 more source

<i>CYFIP1</i> overexpression amplifies IL-6/STAT3 and IFN-γ/STAT1 signaling: potential implications for neuroinflammation and autism spectrum disorder. [PDF]

Brain Behav Immun Health
Martin ER, Martin JG, Russell MA, Oguro-Ando A.   +3 more
europepmc   +1 more source

G3BP1 is a SWI/SNF-bound regulator of transcription that modulates activation of STATs. [PDF]

Biosci Rep
Papadopoulos N, Sarri N, Lennartsson J, Heldin CH.   +3 more
europepmc   +1 more source

SITE-DIRECTED MUTAGENESIS OF STAT1 TRANSCRIPTION FACTOR IN THE STUDY OF INTERFERON-INDUCED DEPRESSION

, 2018
Staab, Julia, Herrmann-Lingen, Christoph, Meyer, Thomas   +2 more
openaire   +1 more source

Endothelial deletion of the neddylation E2 enzyme UBE2M inhibits tumor growth by promoting nonproductive angiogenesis. [PDF]

J Clin Invest
Jiang X, Zhang J, Zhou L, Li Z, Sun N, Xu X, Zhang J, Huang Y, Zhang X, Chen E, Cheng H, Ke Y.   +11 more
europepmc   +1 more source

HEATR1 deficiency enhanced gastric cancer cell PANoptosis to boost anti-tumor immunity. [PDF]

Mol Med
Huang Y, Xu Q, Zhu M, Shen Y, Zhang X.
europepmc   +1 more source