Results 241 to 250 of about 79,832 (300)

Dual Phosphorylation of STAT1 at Y701/S727 by TNFα Drives AIM2-Mediated PANoptosis of Renal Tubular Epithelial Cells and Fibrotic Progression in Renal Allografts. [PDF]

Int J Biol Sci
Han Q, Liu J, Zhang J, Shen Q, Zhang J, Fei S, Chen H, Sun L, Huang Z, Han Z, Tao J, Gu M, Ju X, Tan R.   +13 more
europepmc   +1 more source

Advancing IBD Management: A Literature Review on the Role of Non‐Invasive Blood‐Based Biomarkers in Predicting and Assessing Pharmacodynamic Response to Treatment

Clinical and Translational Science, Volume 19, Issue 5, May 2026.
ABSTRACT Reliable biomarkers that enable noninvasive, longitudinal assessment of disease activity and therapeutic response remain a major unmet need in inflammatory bowel disease (IBD). While colonic biopsies are the gold standard for evaluating mucosal inflammation, their invasive nature and limited spatial and temporal resolution constrain their ...
Mohamed Hassanein, Li Xi, Rathi D. Ryan, Zhan (Harold) Ye, Nessy Tania, Yamato Sano, Joshua Varghese, Diogo Branquinho, Anna Sapone   +8 more
wiley   +1 more source

Identification of miR‐150‐5p in Human Amniotic Membrane Mesenchymal Cell‐Derived Extracellular Vesicles as a Novel Mechanism Driving Cardioprotection

European Journal of Clinical Investigation, Volume 56, Issue 5, May 2026.
Human amniotic membrane mesenchymal stem cells (hAMSCs) provide significant cardioprotection following myocardial ischemia/reperfusion injury. They improve cardiac function and reduce fibrosis by modulating the MIAT/miR‐150‐5p/HOXA4 signalling axis.
Nunzio Alcharani, Laura Tesoro, Javier Díez‐Mata, José Luis Zamorano, Marta Saura, Maite Iglesias, Carlos Zaragoza   +6 more
wiley   +1 more source

PCIF1 Attenuates Type I Interferon Induction by Inhibiting IRF3 Activation in a Methyltransferase-Independent Manner. [PDF]

Cells
Kano R, Oyama C, Ikeda C, Inujima A, Koizumi K, Akichika S, Suzuki T, Tanaka A, Ohkuma Y, Hirose Y.   +9 more
europepmc   +1 more source

Multiscale Approximations to Understand the Complex Role of Microglia in Alzheimer's Disease

European Journal of Neuroscience, Volume 63, Issue 9, May 2026.
Microglia are dynamic, context‐dependent regulators of Alzheimer's disease, modulating amyloid, tau, and neurodegeneration across disease stages. Integrating multiscale and human‐focused approaches is essential to translate microglial biology into therapeutic strategies. ABSTRACT Microglia, the resident innate immune cells of the central nervous system,
Patricia Martínez‐Tazo, Marina Mejias‐Ortega, Verónica López‐López, Aysha M. Bhojwani‐Cabrera, Emma Saxton, Santiago Canals, Giles Hardingham, Antonia Gutierrez, Jose P. Lopez‐Atalaya, Silvia De Santis   +9 more
wiley   +1 more source

Signal Transducers and Activators of Transcription 1 (STAT1), STAT2, and T Cells Mediate Interferon-Dependent Protection Against Neurobrucellosis. [PDF]

J Infect Dis
Moley CR, Abushahba MFN, Ponzilacqua-Silva B, Kochetkova I, Jackson CD, Skyberg JA.   +5 more
europepmc   +1 more source

The immune-related microRNA miR-146b is upregulated in glioblastoma recurrence [PDF]

, 2018
Badiyan, Shahed N, Cai, Chunyu, Huang, Jiayi, Khwaja, Shariq S, Wang, Xiaowei   +4 more
core   +1 more source

Exosomal Non‐Coding RNAs in Gastrointestinal Cancer Drug Resistance: A Systematic Review of Emerging Mechanisms and Clinical Implications

Journal of Cellular and Molecular Medicine, Volume 30, Issue 9, May 2026.
ABSTRACT Gastrointestinal (GI) tumours are one of the most prevalent cancers globally. Even with normal GI function, individuals may develop neoplasms, highlighting the need to better understand the underlying causes of tumorigenesis. The emergence of tumour drug resistance represents the main reason for the failure of drug treatment; thus, it is ...
Mohsen Sharif‐zak, Zahra Sadeghloo, Fateme Binayi, Stefania Nobili, Sara Ashtari, Amir Sadeghi, Nayeralsadat Fatemi   +6 more
wiley   +1 more source

Systems-Level Analysis of HPAI H5N1 Infection in Ducks: Integrating Transcriptomic, Proteomic, and Phosphoproteomic Data. [PDF]

Int J Mol Sci
Vijayakumar P, Mishra A, Rajamanickam K, Raut AA.   +3 more
europepmc   +1 more source

Comprehensive Analysis Reveals Potential Molecular Targets in Juvenile Dermatomyositis. [PDF]

Biochem Res Int
Chen C, Qiao H.
europepmc   +1 more source