Results 261 to 270 of about 4,584,115 (291)

Transcription factor STAT1 gene polymorphism is associated with the development of severe forms of periodontal disease

Inflammation Research, 2013
Periodontal disease (PD) is one of the most common inflammatory diseases, affecting about 10 % of the world population. The establishment of PD is influenced by polymorphisms in genes involved with the inflammatory response. Signal Transducer and Activator of Transcription (STAT)-1 is a transcription factor that plays a key role in the intracellular ...
Adriana Machado, Saraiva, Jeane, de Fátima Correia Silva, Micena Roberta Miranda, Alves e Silva, José Eustáquio, da Costa, Kenneth J, Gollob, Paula Rocha, Moreira, Walderez Ornelas, Dutra   +6 more
openaire   +2 more sources

Activation of transcription factors STAT1 and STAT5 in the mouse median eminence after systemic ciliary neurotrophic factor administration

Brain Research, 2015
Exogenously administered ciliary neurotrophic factor (CNTF) causes weight loss in obese rodents and humans through leptin-like activation of the Jak-STAT3 signaling pathway in hypothalamic arcuate neurons. Here we report for the first time that 40min after acute systemic treatment, rat recombinant CNTF (intraperitoneal injection of 0.3mg/kg of body ...
Ilenia, Severi, Martina, Senzacqua, Eleonora, Mondini, Francesca, Fazioli, Saverio, Cinti, Antonio, Giordano   +5 more
openaire   +2 more sources

Transcription Factor STAT1 Promotes the Proliferation, Migration and Invasion of Nasopharyngeal Carcinoma Cells by Upregulating LINC01160

Future Oncology, 2020
Aim: To investigate the role of LINC01160 in nasopharyngeal carcinoma (NPC). Materials & methods: Using NPC cells CNE-2 and HNE-2 in vitro, we performed quantitative PCR to determine mRNA expression and western blotting to determine protein expression.
Jingang Ai, Guolin Tan, Tiansheng Wang, Wei Li, Ru Gao, Yexun Song, Shanshan Xiong, Xiang Qing   +7 more
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Differential roles for Th1 transcription factors STAT1 and STAT4 during visceral leishmaniasis (43.22)

The Journal of Immunology, 2012
Abstract Leishmaniasis is a tropical disease caused by protozoan parasites belonging to the genus Leishmania. Leishmania donovani causes visceral disease (VL) with tropism for reticuloendothelial organs. Left untreated, L. donovani infections are fatal, often due to secondary bacterial infections and complications resulting from profound
Heidi Snider, Gaurav Gupta, Abhay Satoskar   +2 more
openaire   +1 more source

[The role of SRC kinase in activation of transcription factor STAT1].

Tsitologiia, 2002
Transcription factor STAT1 (Signal Transducers and Activators of Transcription) takes part in signal transduction from receptors of growth factors and many cytokines, including interferons. In this paper, the role of tyrosinkinases Src and JAK2 was estimated in activation of STAT1 by epidermal growth factor (EGF) and hyperosmotic shock.
K P, Vasilenko, P A, Butylin, A M, Arnautov, N N, Nikol'skiĭ   +3 more
openaire   +1 more source

Activation of STAT1 transcription factor precedes up-regulation of coxsackievirus–adenovirus receptor during viral myocarditis

Cardiovascular Pathology, 2008
The coxsackievirus-adenovirus receptor (CAR) was originally described as a transmembrane protein involved in viral infection and was later found to be required for normal heart development. However, the role of CAR in virus-induced myocarditis has not been investigated so far.
Volker, Ruppert, Thomas, Meyer, Sabine, Pankuweit, Thuridur, Jonsdottir, Bernhard, Maisch   +4 more
openaire   +2 more sources

Inhibition of transcription factor Stat1 activity in mononuclear cell cultures and T cells by the cyclic AMP signaling pathway

The Journal of Immunology, 1996
Abstract Activation of T cells results in a cascade of gene activation and subsequent proliferation and differentiation into effector phenotypes. The regulation of transcription factors belonging to the signal transducer and activator of transcription (STAT) family was analyzed in PHA-activated mononuclear cells and in purified T cells ...
L B, Ivashkiv, E M, Schmitt, A, Castro
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IFN-γ induces a p91/Stat1 α-related transcription factor with distinct activation and binding properties

The Journal of Immunology, 1995
Abstract The 5' flanking region of the mig gene, a member of the chemokine family of small m.w. chemoattractant and growth regulatory factors, contains an IFN-γ-responsive enhancer, γ RE-1, consisting of an extended imperfect palindrome.
N B Guyer, C W Severns, P Wong, C A Feghali, T M Wright   +4 more
openaire   +1 more source

[Effect of nocodazole on the activation of transcription factors STAT1 and STAT3 in A431 cells].

Tsitologiia, 2005
The STAT transcription factors (signal transducers and activators of transcription), STAT1 and STAT3, are involved in signal transduction from growth factors and different cytokine receptors. STAT1 and STAT3 activation mechanisms are not sufficiently investigated, but they are known to depend upon both cell type and stimulus for either of them ...
K P, Vasilenko, E B, Burova, N A, Vinogradova, N N, Nikol'skiĭ   +3 more
openaire   +1 more source

The role of apoptosis and of the human transcription factor STAT1 for the intracellular defense against Trypanosoma cruzi

2015
Das Protozoon Trypanosoma cruzi (T. cruzi) ist der Erreger der Chagaskrankheit, einer Zoonose, die mehr als acht Millionen Menschen in Mittel- und Südamerika befällt und zur dilatativen Kardiomyopathie oder Megabildung des Gastrointestinaltrakts führen kann, die mit schwerer Krankheit einhergehen und zum Tode führen. Die
openaire   +1 more source