Results 261 to 270 of about 79,832 (300)

STAT1: A many-sided transcription factor

Russian Journal of Bioorganic Chemistry, 2010
Cell homeostasis is regulated by numerous signaling proteins. Their main task is to process extracellular signals and activate the intracellular cascades of reactions that lead to the modulation of gene activity. One of the important signaling systems is the STAT family, which is comprised of seven members.
I A, Kostanian, A V, Vonarshenko, V M, Lipkin   +2 more
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STAT1 represses hypoxia-inducible factor-1-mediated transcription

Biochemical and Biophysical Research Communications, 2009
Tumor hypoxia is associated with tumor promotion, malignant progression, and resistance to cancer therapy. The hypoxia-induced phenotypic changes in tumors result, at least partially, from the induction of hypoxia-responsive genes, such as chemokine receptor CXCR4.
Miki, Hiroi, Kazumasa, Mori, Yoshiichi, Sakaeda, Jun, Shimada, Yoshihiro, Ohmori   +4 more
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Implication of STAT1 and STAT3 transcription factors in the response to superantigens

Cytokine, 2004
The activation of STAT1 and STAT3 in response to SEB was analyzed in spleen of Balb/c mice. The intraperitoneal injection of the superantigen SEB activated STAT1 and STAT3 in spleen. Activated STAT1 almost completely disappeared in 24 h even though activated STAT3 was present for more than 48 h after SEB injection.
R, Plaza, S, Vidal, J L, Rodriguez-Sanchez, C, Juarez   +3 more
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Assessing Sequence-Specific DNA Binding and Transcriptional Activity of STAT1 Transcription Factor

2010
Continuous nucleocytoplasmic shuttling of signal transducer and activator of transcription (STAT) proteins is a key to understand their function as cytokine-responsive transcription factors. STATs enter the nucleus both by carrier-dependent and carrier-independent transport pathways, and it was previously shown that STAT1 exits the nucleus only after ...
Thomas, Meyer, Uwe, Vinkemeier
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STAT1 and STAT3 Transcription Factors in Inflammation-associated Colon Cancer

2012
Inflammation is a strong promoter of colorectal cancer formation. Colorectal tumor cells establish heterotypic interactions with inflammatory cells in the stroma that are important for tumor angiogenesis and invasiveness. Recent studies in genetically modified mice have identified transcription factors and signaling networks that are implicated in ...
Paulina Rampetsreiter, Robert Eferl
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Transcription Factor STAT1 Promotes the Proliferation, Migration and Invasion of Nasopharyngeal Carcinoma Cells by Upregulating LINC01160

Future Oncology, 2020
Aim: To investigate the role of LINC01160 in nasopharyngeal carcinoma (NPC). Materials & methods: Using NPC cells CNE-2 and HNE-2 in vitro, we performed quantitative PCR to determine mRNA expression and western blotting to determine protein expression.
Jingang Ai, Guolin Tan, Tiansheng Wang, Wei Li, Ru Gao, Yexun Song, Shanshan Xiong, Xiang Qing   +7 more
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Differential roles for Th1 transcription factors STAT1 and STAT4 during visceral leishmaniasis (43.22)

The Journal of Immunology, 2012
Abstract Leishmaniasis is a tropical disease caused by protozoan parasites belonging to the genus Leishmania. Leishmania donovani causes visceral disease (VL) with tropism for reticuloendothelial organs. Left untreated, L. donovani infections are fatal, often due to secondary bacterial infections and complications resulting from profound
Heidi Snider, Gaurav Gupta, Abhay Satoskar   +2 more
openaire   +1 more source

Activation of STAT1 transcription factor precedes up-regulation of coxsackievirus–adenovirus receptor during viral myocarditis

Cardiovascular Pathology, 2008
The coxsackievirus-adenovirus receptor (CAR) was originally described as a transmembrane protein involved in viral infection and was later found to be required for normal heart development. However, the role of CAR in virus-induced myocarditis has not been investigated so far.
Volker, Ruppert, Thomas, Meyer, Sabine, Pankuweit, Thuridur, Jonsdottir, Bernhard, Maisch   +4 more
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Activation of transcription factors STAT1 and STAT5 in the mouse median eminence after systemic ciliary neurotrophic factor administration

Brain Research, 2015
Exogenously administered ciliary neurotrophic factor (CNTF) causes weight loss in obese rodents and humans through leptin-like activation of the Jak-STAT3 signaling pathway in hypothalamic arcuate neurons. Here we report for the first time that 40min after acute systemic treatment, rat recombinant CNTF (intraperitoneal injection of 0.3mg/kg of body ...
Ilenia, Severi, Martina, Senzacqua, Eleonora, Mondini, Francesca, Fazioli, Saverio, Cinti, Antonio, Giordano   +5 more
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Transcription factor STAT1 gene polymorphism is associated with the development of severe forms of periodontal disease

Inflammation Research, 2013
Periodontal disease (PD) is one of the most common inflammatory diseases, affecting about 10 % of the world population. The establishment of PD is influenced by polymorphisms in genes involved with the inflammatory response. Signal Transducer and Activator of Transcription (STAT)-1 is a transcription factor that plays a key role in the intracellular ...
Adriana Machado, Saraiva, Jeane, de Fátima Correia Silva, Micena Roberta Miranda, Alves e Silva, José Eustáquio, da Costa, Kenneth J, Gollob, Paula Rocha, Moreira, Walderez Ornelas, Dutra   +6 more
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