Results 251 to 260 of about 4,584,115 (291)

OTUD5 maintains STAT1/2 stability and promotes IFNγ-driven intestinal inflammation. [PDF]

J Biol Chem
Guan H, Cai C, Wang J, Liu Z, Peng J, Bai X, Wu L, Jiang K, Zhen X, Yu C, Zhang P, Shen Z.   +11 more
europepmc   +1 more source

An iguratimod prodrug reduces RA-FLS invasiveness by disrupting STAT1-C3-TNFα-mediated crosstalk between fibroblast-like synoviocytes and macrophages. [PDF]

J Orthop Translat
Tao L, Jiang W, Huang Y, Fu X, Wang H, Yang H, Li H, Tian Z, Liu D, Wang S, Zhu Y.   +10 more
europepmc   +1 more source

Inhibition of p300/CREBBP catalytic activity drives context-dependent transcriptional activation in AML.

Blood
Meyerhöfer M, Zhou Y, Gallego-Crespo A, Shah V, Behrendt M, Saura-Panella M, Häupl B, Todoriuk O, Hartmann M, Klein M, Wölfel C, Hähnel PS, Michel CS, Muth S, Kindler T, Bopp T, Schild H, Horton SJ, Radsak M, Theobald M, Vassiliou GS, Huntly BJP, Kühn MWM, Butter F, Oellerich T, Sasca D.   +25 more
europepmc   +1 more source

CDK8 Kinase Phosphorylates Transcription Factor STAT1 to Selectively Regulate the Interferon Response [PDF]

Immunity, 2013
Gene regulation by cytokine-activated transcription factors of the signal transducer and activator of transcription (STAT) family requires serine phosphorylation within the transactivation domain (TAD). STAT1 and STAT3 TAD phosphorylation occurs upon promoter binding by an unknown kinase.
Birgit Strobl, Lars Dölken, Mathias Müller   +2 more
exaly   +3 more sources

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STAT1: A many-sided transcription factor

Russian Journal of Bioorganic Chemistry, 2010
Cell homeostasis is regulated by numerous signaling proteins. Their main task is to process extracellular signals and activate the intracellular cascades of reactions that lead to the modulation of gene activity. One of the important signaling systems is the STAT family, which is comprised of seven members.
I A, Kostanian, A V, Vonarshenko, V M, Lipkin   +2 more
openaire   +2 more sources

Implication of STAT1 and STAT3 transcription factors in the response to superantigens

Cytokine, 2004
The activation of STAT1 and STAT3 in response to SEB was analyzed in spleen of Balb/c mice. The intraperitoneal injection of the superantigen SEB activated STAT1 and STAT3 in spleen. Activated STAT1 almost completely disappeared in 24 h even though activated STAT3 was present for more than 48 h after SEB injection.
R, Plaza, S, Vidal, J L, Rodriguez-Sanchez, C, Juarez   +3 more
openaire   +2 more sources

STAT1 represses hypoxia-inducible factor-1-mediated transcription

Biochemical and Biophysical Research Communications, 2009
Tumor hypoxia is associated with tumor promotion, malignant progression, and resistance to cancer therapy. The hypoxia-induced phenotypic changes in tumors result, at least partially, from the induction of hypoxia-responsive genes, such as chemokine receptor CXCR4.
Miki, Hiroi, Kazumasa, Mori, Yoshiichi, Sakaeda, Jun, Shimada, Yoshihiro, Ohmori   +4 more
openaire   +2 more sources

Assessing Sequence-Specific DNA Binding and Transcriptional Activity of STAT1 Transcription Factor

2010
Continuous nucleocytoplasmic shuttling of signal transducer and activator of transcription (STAT) proteins is a key to understand their function as cytokine-responsive transcription factors. STATs enter the nucleus both by carrier-dependent and carrier-independent transport pathways, and it was previously shown that STAT1 exits the nucleus only after ...
Thomas, Meyer, Uwe, Vinkemeier
openaire   +2 more sources

STAT1 and STAT3 Transcription Factors in Inflammation-associated Colon Cancer

2012
Inflammation is a strong promoter of colorectal cancer formation. Colorectal tumor cells establish heterotypic interactions with inflammatory cells in the stroma that are important for tumor angiogenesis and invasiveness. Recent studies in genetically modified mice have identified transcription factors and signaling networks that are implicated in ...
Paulina Rampetsreiter, Robert Eferl
openaire   +1 more source