Results 221 to 230 of about 250,824 (344)

STAT3 SH2 Domain Aspartic Acid 661 Mutations Activate Immune Gene Programs. [PDF]

J Cell Mol Med
Lee HK, Cho G, Chen J, Schultz AB, Lee SG, Liu C, Furth PA, Young NS, Kim J, Villarino A, Hennighausen L.   +10 more
europepmc   +1 more source

STAT3 Regulation of Citrate Synthase Is Essential during the Initiation of Lymphocyte Cell Growth [PDF]

, 2017
Sarah MacPherson, Michael Horkoff, Cleo Gravel, Thomas Hoffmann, Johannes Zuber, Julian J. Lum   +5 more
openalex   +1 more source

Micro‐Organ Chip Deciphers Tumor‐Derived G‐CSF as Remote Commander of Lung Pre‐Metastatic Niche via VEGFA‐KDR Cascade

Advanced Science, EarlyView.
Breast cancer reprograms the lung into a receptive pre‐metastatic niche via a novel G‐CSF–VEGFA–KDR signaling axis. Using a micro‐organ chip that enables contact‐independent coculture, this study uncovers how tumor‐secreted G‐CSF activates lung capillary KDR to drive angiogenesis and prime the soil for metastasis—without direct tumor contact.
Jingxin Zhang, Xiaoying Huang, Lingchuan Ma, Zixing Chen, Tianyao Li, Lijian Wang, Yutong Guo, Hu Xu, Junqi Li, Jiang‐Jiang Qin, Xiang Wang, Yuhong Cao, Kai Miao   +12 more
wiley   +1 more source

Cangfu Daotan decoction treats PCOS-IR through the IL6/JAK2/STAT3/FOXO4 signaling pathway. [PDF]

Front Endocrinol (Lausanne)
Ju W, Zhang Q, Wang Y, Pan K, Li Y, Zhao S, Lian F.   +6 more
europepmc   +1 more source

A DNA Tetrahedron Delivery Asiatic Acid to Reprogram Mitochondrial Metabolism for Promoting Bone Regeneration via STAT3 Phosphorylation

Advanced Science, EarlyView.
A hyaluronic acid methacrylate (HAMA) hydrogel incorporating DNA tetrahedrons loaded with Asiatic acid (TDN@AA) was developed. HM‐TDN@AA promotes angiogenesis of endothelial cells (ECs), inhibits osteoclastogenesis from bone marrow–derived macrophages (BMDMs), and enhances osteogenesis of mesenchymal stem cells (MSCs) via STAT3‐mediated mitochondrial ...
Yiwen Huang, Yiming Zhang, Yisheng Feng, Qixiang Yang, Beiyuan Gao, Haiyang Xu, Cheng Huang, Kaili Lin, Yuanzhi Xu, Peiqi Zhu   +9 more
wiley   +1 more source

MicroR-15b-5p targets JAK2/STAT3 signaling pathway to regulate glucose and lipid metabolism in primary chicken hepatocytes. [PDF]

Poult Sci
Zeng W, Yang L, Zeng C, Cheng X, Cao P, Xing C, Zhang C, Cao H, Guo X, Hu G, Zhuang Y.   +10 more
europepmc   +1 more source

Trojan Horse Strategy: How Biomimetic Nanomedicine Remodels the Tumor Microenvironment

Advanced Science, EarlyView.
This review focuses on biomimetic nanomedicines for tumor microenvironment (TME) remodeling, covering their diverse biomimetic types, design principles, and mechanisms of immune cell reprogramming and reversal of immunosuppressive microenvironments, with particular emphasis on their application in synergistic immunotherapy.
Wanrong Wang, Siqi Mu, Juan Zhang, Guisong Shan, Xueqian Li, Ran Wang, Tao Guo, Xiaoyan He   +7 more
wiley   +1 more source

SOX11 Is Regulated by EGFR-STAT3 and Promotes Epithelial-Mesenchymal Transition in Head and Neck Squamous Cell Carcinoma. [PDF]

Cells
Peng J, Cui L, Guo M, Liu Y, Jia W, Misuno K, Barrett J, Messadi D, Yang SF, Hu S.   +9 more
europepmc   +1 more source

Supplementary Figure 2 from Targeting Stat3 in the Myeloid Compartment Drastically Improves the <i>In vivo</i> Antitumor Functions of Adoptively Transferred T Cells

, 2023
Andreas Herrmann, Marcin Kortylewski, Maciej Kujawski, Chunyan Zhang, Karen L. Reckamp, Brian Armstrong, Lin Wang, Claudia Kowolik, Jiehui Deng, Robert A. Figlin, Hua Yu   +10 more
openalex   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source