Results 231 to 240 of about 179,101 (246)
Some of the next articles are maybe not open access.
Heart Failure Reviews, 2010
Multiple in vitro and in vivo studies showed that the signal transducer and activator of transcription 3 (STAT3) protein is involved in cardiomyocyte protection and hypertrophy and via paracrine pathways impacts on the non-myocyte compartment, i.e., the vasculature and the extracellular matrix.
Arash, Haghikia +3 more
openaire +2 more sources
Multiple in vitro and in vivo studies showed that the signal transducer and activator of transcription 3 (STAT3) protein is involved in cardiomyocyte protection and hypertrophy and via paracrine pathways impacts on the non-myocyte compartment, i.e., the vasculature and the extracellular matrix.
Arash, Haghikia +3 more
openaire +2 more sources
STAT3: a multifaceted oncoprotein
Growth Factors, 2018Signal transducer and activator of transcription (STAT) 3 is a key signalling protein engaged by a multitude of growth factors and cytokines to elicit diverse biological outcomes including cellular growth, differentiation, and survival. The complete loss of STAT3 is not compatible with life and even partial loss of function mutations lead to ...
Aleks C. Guanizo +3 more
openaire +2 more sources
Nature Reviews Cancer, 2018
D’Amico et al. show that, in the presence of oncogenic RAS mutations, STAT3 acts as a tumour modifier by regulating the epithelial differentiation of pancreatic and lung cancer cells via p63.
openaire +2 more sources
D’Amico et al. show that, in the presence of oncogenic RAS mutations, STAT3 acts as a tumour modifier by regulating the epithelial differentiation of pancreatic and lung cancer cells via p63.
openaire +2 more sources
Nature Reviews Cancer, 2018
Priego et al. show that a subpopulation of reactive astrocytes expressing signal transducer and activator of transcription 3 (STAT3) is crucial for the development of brain metastases and report positive initial clinical data that inhibiting STAT3 can reduce metastasis.
openaire +2 more sources
Priego et al. show that a subpopulation of reactive astrocytes expressing signal transducer and activator of transcription 3 (STAT3) is crucial for the development of brain metastases and report positive initial clinical data that inhibiting STAT3 can reduce metastasis.
openaire +2 more sources
2003
STAT3 is perhaps the STAT family member whose physiological functions are less well understood. It was initially identified as Acute Phase Response Factor (APRF), a DNA-binding activity appearing in IL-6-treated hepatocytes and interacting with an Acute Phase Response Element (APRE) on the promoter of several IL-6-responsive genes (1).
POLI, Valeria, ALONZI T.
openaire +2 more sources
STAT3 is perhaps the STAT family member whose physiological functions are less well understood. It was initially identified as Acute Phase Response Factor (APRF), a DNA-binding activity appearing in IL-6-treated hepatocytes and interacting with an Acute Phase Response Element (APRE) on the promoter of several IL-6-responsive genes (1).
POLI, Valeria, ALONZI T.
openaire +2 more sources
Science's STKE, 2003
Signal transducer and activator of transcription 3 (STAT3) is widely expressed and activated by various growth-regulating signals, as well as diverse cytokines, that activate gp130 signaling receptors. Hence, STAT3 is critical for embryonic development and stem cell biology, as well as inflammation, growth regulation, and multiple immune ...
D. S. Aaronson, C. M. Horvath
openaire +1 more source
Signal transducer and activator of transcription 3 (STAT3) is widely expressed and activated by various growth-regulating signals, as well as diverse cytokines, that activate gp130 signaling receptors. Hence, STAT3 is critical for embryonic development and stem cell biology, as well as inflammation, growth regulation, and multiple immune ...
D. S. Aaronson, C. M. Horvath
openaire +1 more source
LncRNA STAT3-AS regulates endometrial receptivity via the STAT3 signaling pathway
TheriogenologyEndometrial receptivity is critical for the successful establishment of pregnancy in ruminants. Interferon tau (IFNT) plays a key role in promoting embryo attachment by activating the Janus kinase/signal transducer and activator of transcription pathway, which induces the expression of a series of interferon-stimulated genes (ISGs).
Yanni, Jia +11 more
openaire +2 more sources
Science, 2009
A protein that has a nuclear function as a transcription factor also functions to support respiration in the mitochondria.
openaire +2 more sources
A protein that has a nuclear function as a transcription factor also functions to support respiration in the mitochondria.
openaire +2 more sources
Gan to kagaku ryoho. Cancer & chemotherapy, 2011
Clinical efficacies of various molecular-targeted drugs have been recently demonstrated. Most of these drugs are kinase inhibitors. A most successful drug Glivec is an inhibitor of Bcr-Abl fusion kinase, derived from a well-known causative chromosome translocation of chronic myeloid leukemia(CML). Although other kinase inhibitors have also proved to be
openaire +1 more source
Clinical efficacies of various molecular-targeted drugs have been recently demonstrated. Most of these drugs are kinase inhibitors. A most successful drug Glivec is an inhibitor of Bcr-Abl fusion kinase, derived from a well-known causative chromosome translocation of chronic myeloid leukemia(CML). Although other kinase inhibitors have also proved to be
openaire +1 more source