Results 311 to 320 of about 273,588 (361)

Kaempferol attenuates LPS-induced inflammatory responses in H9c2 cells through involvement of the IL-6/JAK2/STAT3 pathway. [PDF]

Mol Biol Rep
Yue H, Jia Y, Sun R, Liao H, Zuo Y, Wang P, Li W.   +6 more
europepmc   +1 more source

G3BP1 is a SWI/SNF-bound regulator of transcription that modulates activation of STATs. [PDF]

Biosci Rep
Papadopoulos N, Sarri N, Lennartsson J, Heldin CH.   +3 more
europepmc   +1 more source

Microglial Inhibition Promotes Proliferation and Differentiation of Neural Stem Cells via STAT3/SDF-1/CXCR4 Signaling Pathway in Hypoxic-Ischemic Encephalopathy. [PDF]

Glia
Ding A, Duan G, Zhu M, Chen L, Luo J, Tan T, Li Z, Wang W, Wang J, Chen Y, Tang YP.   +10 more
europepmc   +1 more source

IL-10-STAT3 axis preserves epithelial mitochondrial homeostasis during bacterial challenge. [PDF]

Gut Microbes
Navaneetha Krishnan S, Jaiswal A, Mohan A, Wang A, E Shutt T, McKay DM.   +5 more
europepmc   +1 more source

DNER drives glycolytic reprogramming in renal cell carcinoma by activating the JAK2/STAT3 signaling pathway. [PDF]

Front Immunol
Li A, Xu JW, Qin JH, Yuan Q, Teng L.
europepmc   +1 more source

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Targeting the STAT3 pathway with STAT3 degraders

Trends in Pharmacological Sciences
Signal transducer and activator of transcription 3 (STAT3) has been widely considered as a therapeutic target for various diseases, especially tumors. Thus far, several STAT3 inhibitors have been advanced to clinical trials; however, the development of STAT3 inhibitors is hindered by numerous dilemmas.
Zhijie Wang, Xia Guo, Jianjun Chen
exaly   +3 more sources

STAT3-EMT axis in tumors: modulation of cancer metastasis, stemness and therapy response.

Pharmacological Research, 2022
Epithelial-to-mesenchymal transition (EMT) mechanism is responsible for metastasis of tumor cells and their spread to various organs and tissues of body, providing undesirable prognosis.
Mehrdokht Sadrkhanloo, M. Entezari, Sima Orouei, Marzieh Ghollasi, N. Fathi, Shamin Rezaei, E. Hejazi, Amirabbas Kakavand, Hamidreza Saebfar, M. Hashemi, Mohammad Ali Sheikh Beig Goharrizi, Shokooh Salimimoghadam, M. Rashidi, A. Taheriazam, S. Samarghandian   +14 more
semanticscholar   +1 more source

Recent Update on Development of Small-Molecule STAT3 Inhibitors for Cancer Therapy: From Phosphorylation Inhibition to Protein Degradation.

Journal of Medicinal Chemistry, 2021
Signal transducer and activator of transcription 3 (STAT3) is a transcription factor that regulates various biological processes, including proliferation, metastasis, angiogenesis, immune response, and chemoresistance.
Jinyun Dong, Xiang-dong Cheng, Wei-Dong Zhang, Jiangjiang Qin   +3 more
semanticscholar   +1 more source

Electrochemical detection of the Fc-STAT3 phosphorylation and STAT3–Fc-STAT3 dimerization and inhibition

Molecular BioSystems, 2013
Abstract Signal transducer and activator of transcription 3 (STAT3) protein is involved in regulatory functions in cell proliferation, differentiation and survival, and is linked to cancer phenotype and tumorigenesis. Towards developing new methodologies for screening STAT3 interactions, the electrochemical method based on the use of ...
S, Martic, M K, Rains, S, Haftchenary, V M, Shahani, D, Kraskouskaya, D P, Ball, P T, Gunning, H B, Kraatz   +7 more
openaire   +2 more sources

STAT3 on the brain

Nature Reviews Cancer, 2018
Priego et al. show that a subpopulation of reactive astrocytes expressing signal transducer and activator of transcription 3 (STAT3) is crucial for the development of brain metastases and report positive initial clinical data that inhibiting STAT3 can reduce metastasis.
openaire   +2 more sources