Results 321 to 330 of about 273,588 (361)
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Science's STKE, 2006
STAT3, a member of the signal transducer and activator of transcription (STAT) family of transcription factors, is a known regulator of cell motility through its transcriptional activating functions. However, new evidence suggests a novel role for non–tyrosine-phosphorylated and cytoplasmically localized STAT3 in mediating cell migration by disrupting ...
S Paul, Gao, Jacqueline F, Bromberg
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STAT3, a member of the signal transducer and activator of transcription (STAT) family of transcription factors, is a known regulator of cell motility through its transcriptional activating functions. However, new evidence suggests a novel role for non–tyrosine-phosphorylated and cytoplasmically localized STAT3 in mediating cell migration by disrupting ...
S Paul, Gao, Jacqueline F, Bromberg
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Heart Failure Reviews, 2010
Multiple in vitro and in vivo studies showed that the signal transducer and activator of transcription 3 (STAT3) protein is involved in cardiomyocyte protection and hypertrophy and via paracrine pathways impacts on the non-myocyte compartment, i.e., the vasculature and the extracellular matrix.
Arash, Haghikia +3 more
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Multiple in vitro and in vivo studies showed that the signal transducer and activator of transcription 3 (STAT3) protein is involved in cardiomyocyte protection and hypertrophy and via paracrine pathways impacts on the non-myocyte compartment, i.e., the vasculature and the extracellular matrix.
Arash, Haghikia +3 more
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SH3BGRL3, transcribed by STAT3, facilitates glioblastoma tumorigenesis by activating STAT3 signaling
Biochemical and Biophysical Research Communications, 2021Glioblastoma (GBM) is the most aggressive tumors of the central nervous system. Here, we report that SH3 binding glutamic acid-rich protein like 3 (SH3BGRL3) was extremely highly expressed in GBM and glioma stem cells. SH3BGRL3 high expression associates with worse survival of GBM patients.
Zhi, Nie +5 more
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STAT3: a multifaceted oncoprotein
Growth Factors, 2018Signal transducer and activator of transcription (STAT) 3 is a key signalling protein engaged by a multitude of growth factors and cytokines to elicit diverse biological outcomes including cellular growth, differentiation, and survival. The complete loss of STAT3 is not compatible with life and even partial loss of function mutations lead to ...
Aleks C. Guanizo +3 more
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Abstract 1404: Novel STAT3 inhibitors targeting the STAT3 dimerization
Cancer Research, 2022Abstract Background The STAT3 pathway may drive prostate cancer (PCa) progression to metastatic castration-resistant prostate cancer (mCRPC). STAT3 may serve as a good target for the treatment of prostate cancer. The function of STAT3 relies significantly on its SH2 domain, which promotes STAT3 homo- or hetero-dimerization, protein ...
Yaping Hua +3 more
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Targeting STAT3 signaling pathway in cancer by agents derived from Mother Nature.
Seminars in Cancer Biology, 2020Signal transducer and activator of transcription (STAT) proteins are latent transcription factors that reside in the cytoplasm of several types of cells.
C. D. Mohan +7 more
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Medicinal research reviews (Print), 2020
Signal transducer and activator of transcription 3 (STAT3) is one of the crucial transcription factors, responsible for regulating cellular proliferation, cellular differentiation, migration, programmed cell death, inflammatory response, angiogenesis ...
M. Garg +10 more
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Signal transducer and activator of transcription 3 (STAT3) is one of the crucial transcription factors, responsible for regulating cellular proliferation, cellular differentiation, migration, programmed cell death, inflammatory response, angiogenesis ...
M. Garg +10 more
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Gut, 2019
Objective Cancer-associated fibroblasts (CAFs) influence the tumour microenvironment and tumour growth. However, the role of CAFs in colorectal cancer (CRC) development is incompletely understood.
Christina Heichler +24 more
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Objective Cancer-associated fibroblasts (CAFs) influence the tumour microenvironment and tumour growth. However, the role of CAFs in colorectal cancer (CRC) development is incompletely understood.
Christina Heichler +24 more
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Science's STKE, 2003
Signal transducer and activator of transcription 3 (STAT3) is widely expressed and activated by various growth-regulating signals, as well as diverse cytokines, that activate gp130 signaling receptors. Hence, STAT3 is critical for embryonic development and stem cell biology, as well as inflammation, growth regulation, and multiple immune ...
D. S. Aaronson, C. M. Horvath
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Signal transducer and activator of transcription 3 (STAT3) is widely expressed and activated by various growth-regulating signals, as well as diverse cytokines, that activate gp130 signaling receptors. Hence, STAT3 is critical for embryonic development and stem cell biology, as well as inflammation, growth regulation, and multiple immune ...
D. S. Aaronson, C. M. Horvath
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The decreased expression of Stat3 and p-Stat3 in preeclampsia-like rat placenta
Journal of Molecular Histology, 2018This study aims to investigate the expression of Stat3 and p-Stat3 in the placenta of a preeclampsia-like rat model induced by Nωnitro-L-arginine methyl ester (L-NAME). Two-to three-month-old (20 males, 40 females) Sprague-Dawley rats were used in this study.
Zhan Zhang +3 more
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