Results 101 to 110 of about 833,114 (323)

Yin Yang 1 is associated with cancer stem cell transcription factors (SOX2, OCT4, BMI1) and clinical implication. [PDF]

, 2016
The transcription factor Yin Yang 1 (YY1) is frequently overexpressed in cancerous tissues compared to normal tissues and has regulatory roles in cell proliferation, cell viability, epithelial-mesenchymal transition, metastasis and drug/immune resistance.
Bonavida, Benjamin, Garbán, Hermes, Kaufhold, Samantha   +2 more
core   +2 more sources

A recessive form of hyper-IgE syndrome by disruption of ZNF341-dependent STAT3 transcription and activity

Science immunology, 2018
ZNF341 is a newly characterized transcription factor controlling baseline and inducible transcription of the human STAT3 gene. Fingers on the trigger Hyper–immunoglobulin E syndromes (HIESs) are rare genetic immunodeficiency diseases characterized by ...
V. Béziat, Juan Li, Jian-Xin Lin, Cindy S. Ma, Peng Li, A. Bousfiha, I. Pellier, S. Zoghi, S. Barış, S. Keleş, P. Gray, Ning Du, Yi Wang, Y. Zerbib, R. Lévy, T. Leclercq, Frédégonde About, A. Lim, Geetha Rao, K. Payne, Simon J. Pelham, D. Avery, E. Deenick, Bethany A. Pillay, J. Chou, R. Guery, Aziz Belkadi, A. Guérin, M. Migaud, Vimel Rattina, F. Ailal, I. Benhsaien, M. Bouaziz, T. Habib, D. Chaussabel, N. Marr, J. El-Benna, B. Grimbacher, O. Wargon, J. Bustamante, B. Boisson, I. Müller-Fleckenstein, B. Fleckenstein, M. Chandesris, M. Titeux, S. Fraitag, M. Alyanakian, M. Leruez-Ville, C. Picard, I. Meyts, J. D. Di Santo, A. Hovnanian, A. Somer, A. Ozen, N. Rezaei, T. Chatila, L. Abel, W. Leonard, S. Tangye, A. Puel, J. Casanova   +60 more
semanticscholar   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

KLF6 and STAT3 Co-Occupy Regulatory DNA and Functionally Synergize to Promote Axon Growth in CNS Neurons [PDF]

, 2018
The failure of axon regeneration in the CNS limits recovery from damage and disease. Members of the KLF family of transcription factors can exert both positive and negative effects on axon regeneration, but the underlying mechanisms are unclear.
Blackmore, Murray G., Eastwood, Dan C., Holan, Lyndsey, Maunze, Brian, Mehra, Vatsal, Simpson, Matthew T., Venkatesh, Ishwariya, Wang, Zimei   +7 more
core   +1 more source

Epidermal growth factor and lipopolysaccharide activate Stat3 transcription factor in mouse liver.

Journal of Biological Chemistry, 1994
Previous studies demonstrated that the intraperitoneal injection of epidermal growth factor (EGF) into mice resulted in the appearance, within minutes, of several tyrosine-phosphorylated proteins in liver nuclei. Two of these proteins have been identified as the transcription factors p91/p84 (Stat1 alpha/1 beta) (Ruff-Jamison, S., Chen, K., and Cohen ...
Ruff-Jamison, Susan, Zhong, Zhong, Wen, Zilong, Chen, Katherine, Darnell, James E., Cohen, Stanley W.   +5 more
openaire   +2 more sources

Sequestration of the Transcription Factor STAT3 by the Molecular Chaperone CCT: A Potential Mechanism for Modulation of STAT3 Phosphorylation

Journal of Molecular Biology, 2021
Chaperonin Containing Tailless complex polypeptide 1 (CCT) is an essential molecular chaperone required for the folding of the abundant proteins actin and tubulin. The CCT oligomer also folds a range of other proteins and participates in non-folding activities such as providing assembly support for complexes of the von Hippel Lindau tumor suppressor ...
Josefine, Vallin, Carmen M, Córdoba-Beldad, Julie, Grantham   +2 more
openaire   +2 more sources

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Regulation of anti-inflammatory gene expression in vascular endothelial cells by EPAC1 [PDF]

, 2015
Suppressor of cytokine signalling 3 (SOCS3) is a potent inhibitor of pro-inflammatory pathways involved in atherogenesis and the development of neo-intimal hyperplasia (NIH), which contributes to the in-stent re-stenosis responsible for the failure of ...
Palmer, Timothy P., Yarwood, Stephen J.
core   +1 more source

Swelling‐Programmed Topographical Guidance for Dynamic Spheroid Self‐Assembly via a Mechanochemical Hydrogel Niche

Advanced Functional Materials, EarlyView.
A swelling‐programmed micropatterned hydrogel guides adherent cells through a controlled transition from cell–matrix anchoring to cadherin‐mediated cell–cell compaction, enabling rapid assembly of high‐viability spheroids with defined size and morphology.
Han Gyeol Nam, Seon Yeong Chae, Young Woo Kwon, Hye Jin Heo, Hye Rin Lee, Ji Hyeok Lee, Dong‐Wook Han, Yun Hak Kim, Suck Won Hong   +8 more
wiley   +1 more source

Special Issue “Role of STAT3 in Oncogenesis”

Biomedicines, 2022
This Biomedicines Special Issue was designed to attract articles that focused on the pleiotropic role of the signal transducer and activator of transcription 3 (STAT3) transcription factor in different facets of tumorigenesis [...]
Kwang Seok Ahn
doaj   +1 more source