Results 121 to 130 of about 833,114 (323)
Theranostics, 2015 Signal transducer and activator of transcription 3 (STAT3) is constitutively activated in many cancers where it acts to promote tumor progression. A STAT3-specific transcription factor decoy has been developed to suppress STAT3 downstream signaling, but ...
Jonathan A. Kopechek +8 more
semanticscholar +1 more source
Hunting for transcription factors: STAT3 decoy in non-small cell lung cancer
Translational Lung Cancer Research, 2018 Non-small cell lung cancer (NSCLC) is by far the most common type of lung cancer and accounts for 84% of all cases. The majority of these patients present at advanced stages that are incurable and have >90% 5-year mortality rate (1). The cellular origin is of unknown etiology and rapidly becomes an incredibly heterogeneous disease containing myriad ...
Joseph, Carmicheal +3 more
openaire +2 more sources
Advanced Healthcare Materials, EarlyView.Ionizable lipid nanoparticles target multiple pathological pathways in neurodegeneration. The designed self‐assembled materials undergo a pH‐triggered structural transformation from a cubosome/hexosome coexistence to a hexosome phase, enhancing intracellular delivery of a multi‐target phytochemical formulation. The antioxidant‐loaded pH‐responsive LNPs
Thelma Akanchise +4 more
wiley +1 more source
STAT1 inhibits STAT3 activation in esophageal squamous cell carcinoma
Cancer Management and Research, 2018 Zhaoyong Liu,1,* Ying Zhang,2,* Yelong Chen,1 Youbin Lin,1 Zhen Lin,2 Hu Wang1 1Department of Orthopaedics, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, China; 2Department of Pathology, Shantou University ...
Liu Z +5 more
doaj
Advanced Healthcare Materials, EarlyView.A superhydrophobic 3D cell culture platform enables rapid and consistent formation of heterotypic tumor–stroma clusters, and reveals how physiological shear conditions influence metastatic signaling. Mechanical stimulation of cancer‐associated fibroblasts promotes sustained cytokine secretion and survival‐promoting pathways, showing how multicellular ...
Alexandria T. Carter +5 more
wiley +1 more source
The PGE2-Stat3 interaction in doxorubicin-induced myocardial apoptosis [PDF]
, 2017 Aims Both cyclooxygenase-2 (COX-2) and the transcription factor signal transducer and activator of transcription 3 (Stat3) are involved in adaptive growth and survival of cardiomyocytes. In ventricular cardiomyocytes, prostaglandin E2 (PGE2), a major COX-
Frias, Miguel A. +5 more
core
YAP integrates the regulatory Snail/HNF4α circuitry controlling epithelial/hepatocyte differentiation [PDF]
, 2019 Yes-associated protein (YAP) is a transcriptional co-factor involved in many cell processes, including development, proliferation, stemness, differentiation, and tumorigenesis.
Amicone, Laura +8 more
core +1 more source
Advanced Materials, EarlyView.Controlling the protein corona formation onto carbon nanomaterials (CNMs) enhances their functionalities as platforms for cancer theranostics. Here, we reviewed the effects of the intrinsic and acquired properties of CNMs on protein corona formation, the consequent biological and toxicological outcomes, and the strategies to reshape corona formation ...
Yajuan Zou +5 more
wiley +1 more source
How should we define STAT3 as an oncogene and as a potential target for therapy? [PDF]
, 2013 Aberrant activation of the STAT3 transcription factor has been reported in a large group of tumors and a strong biological basis now defines this protein as an oncogenic driver.
A. Rébillard +4 more
core +3 more sources
Galiellalactone Is a Direct Inhibitor of the Transcription Factor STAT3 in Prostate Cancer Cells*♦
Journal of Biological Chemistry, 2014 Background: STAT3 is constitutively active in castration-resistant prostate cancer and the fungal metabolite galiellalactone inhibits STAT3 signaling. Results: Galiellalactone binds covalently to one or more cysteines in STAT3 and prevents STAT3 binding ...
Nicholas Don-Doncow +8 more
semanticscholar +1 more source