Results 21 to 30 of about 1,054,626 (242)

Programmable Synthetic Protein Circuits for the Identification and Suppression of Hepatocellular Carcinoma

Molecular Therapy: Oncolytics, 2020
Precisely identifying and killing tumor cells are diligent pursuits in oncotherapy. Synthesized gene circuits have emerged as an intelligent weapon to solve these problems.
Xu Han, Jiong Yang, Fanhong Zeng, Jun Weng, Yue Zhang, Qing Peng, Li Shen, Shigang Ding, Kaiyu Liu, Yi Gao   +9 more
doaj   +1 more source

Identification of Radiotherapy-Associated Genes in Lung Adenocarcinoma by an Integrated Bioinformatics Analysis Approach

Frontiers in Molecular Biosciences, 2021
Radiotherapy (RT) plays an important role in the prognosis of lung adenocarcinoma (LUAD) patients, but the radioresistance (RR) of LUAD is still a challenge that needs to be overcome.
Junhao Wang, Qizheng Han, Huizi Liu, Haihua Luo, Lei Li, Aihua Liu, Yong Jiang   +6 more
doaj   +1 more source

Utility of Computed Tomography Surveillance of Asymptomatic Infection in Children and Young Adults Before Allogeneic Hematopoietic Stem Cell Transplant

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Asymptomatic infection poses a significant risk for children undergoing hematopoietic stem cell transplantation (HSCT). Pre‐transplant surveillance computed tomography (CT) is commonly used to identify occult infection, though its diagnostic yield remains uncertain.
Tyler Obermark, Pradipta Debnath, Rama S. Ayyala, Lara A. Danziger‐Isakov, Jane Koo, Kasiani C. Myers, William R. Otto, Aki Tanimoto, Andrew T. Trout, Cara E. Morin   +9 more
wiley   +1 more source

The effects of ultrasound exposure on P-glycoprotein-mediated multidrug resistance in vitro and in vivo

Journal of Experimental & Clinical Cancer Research, 2018
Background Multidrug resistance (MDR) is often responsible for the failure of chemotherapy treatment, and current strategies for cancer MDR are not adequately satisfying as to their efficacy and safety.
Chixiong Huang, Senlin Huang, Hairui Li, Xinzhong Li, Bing Li, Lintao Zhong, Junfeng Wang, Meishen Zou, Xiang He, Hao Zheng, Xiaoyun Si, Wangjun Liao, Yulin Liao, Li Yang, Jianping Bin   +14 more
doaj   +1 more source

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source

Association between admission plasma 2-oxoglutarate levels and short-term outcomes in patients with acute heart failure: a prospective cohort study

Molecular Medicine, 2019
Background 2-oxoglutarate (2OG), an intermediate metabolite in the tricarboxylic acid cycle, has been found to associate with chronic heart failure (HF), but its effect on short-term adverse outcomes in patients with acute HF (AHF) is uncertain.
Zhengliang Peng, Qiong Zhan, Xiangkun Xie, Hanlin Li, Yan Tu, Yujia Bai, Xingfu Huang, Wenyan Lai, Boxin Zhao, Qingchun Zeng, Dingli Xu   +10 more
doaj   +1 more source

Extracellular vesicles of Fusobacterium nucleatum compromise intestinal barrier through targeting RIPK1-mediated cell death pathway

Gut Microbes, 2021
Microbial factors that mediate microbes-host interaction in ulcerative colitis (UC), a chronic disease seriously affecting human health, are not fully known. The emerging oncobacterium Fusobacterium nucleatum (Fn) secretes extracellular vesicles carrying
Le Liu, Liping Liang, Chenghai Yang, Youlian Zhou, Ye Chen   +4 more
doaj   +1 more source

Alveolar Soft Part Sarcoma in Pediatric and Young Adult Patients: A Report From the Children's Oncology Group Study ARST0332

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Alveolar soft part sarcoma (ASPS) is a rare soft tissue sarcoma occurring most commonly in adolescence and young adulthood. Methods We present the clinical characteristics, treatments, and outcomes of patients with newly diagnosed ASPS enrolled on the Children's Oncology Group study ARST0332.
Jacquelyn N. Crane, Wei Xue, Amira Qumseya, Thomas Scharschmidt, Kathryn R. Tringale, Oscar Lopez Nunez, Jiaqi Hu, Donald A. Barkauskas, Rajkumar Venkatramani, Sheri L. Spunt, Aaron R. Weiss, Noah C. Federman   +11 more
wiley   +1 more source

The top tertile of hematocrit change during hospitalization is associated with lower risk of mortality in acute heart failure patients

BMC Cardiovascular Disorders, 2017
Background Hemoconcentration has been proposed as surrogate for changes in volume status among patients hospitalized with acute heart failure (AHF) and is associated with a favorable outcome.
Haobin Zhou, Tianyu Xu, Yuli Huang, Qiong Zhan, Xingfu Huang, Qingchun Zeng, Dingli Xu   +6 more
doaj   +1 more source

Implementing Health‐Related Quality of Life Assessment in Pediatric Oncology: A Feasibility Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background There is growing interest in embedding health‐related quality of life (HRQoL) assessment and patient‐reported outcome measures (PROMs) within clinical cancer care. This study evaluated the feasibility, acceptability, and usability of implementing an electronic PROM (ePROM) platform to measure HRQoL in children with cancer ...
Mikaela Doig, Sophie Jessop, Jordan R. Hansford, Hien Le, Matthew O'Connor, Peter Gorayski, Andrew Cunningham, Amanda Hutchinson, Victoria Bedford, Eva Bezak, Nayana Parange, Kelly Skelton, Timothy Price, Michala Short   +13 more
wiley   +1 more source