Results 91 to 100 of about 3,021,739 (277)
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Confluenze, 2018 Based on the articulation between the idea of an enemy in criminal law and the analysis of the historical importance of racism in the structure of our society, we will analyse how we are facing a real genocide of the black population in Brazil today ...
Mariana Paganote Dornellas +1 more
doaj +1 more source
State v. Burgess: A Limitation on a Defendant’s Right to Remain Innocent [PDF]
, 2010 [Excerpt] “This note will explore the current state of the privilege against self-incrimination, particularly in regard to whether it works to bar negative inferences from being drawn from a defendant’s silence during sentencing in order to determine his
Lahey, Elizabeth
core +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
La emergencia una (nueva) logica de seguridad politica.
Colombia Internacional, 2005 This article explores a series of recent theoretical contributions on the topic of security. Currently, the implementation of practices, processes and political rationalities that aim to administer, regulate and decide over human life, prove to be a ...
Juan Felipe Moreno.
doaj
Should \u3ci\u3eLucas v. South Carolina Coastal Council\u3c/i\u3e Protect Where the Wild Things Are? Of Beavers, Bob-o-Links, and Other Things that Go Bump in the Night [PDF]
, 2000 Lucas v. South Carolina Coastal Council is one of several recent Supreme Court decisions in which the Court used the Just Compensation Clause as a weapon of reaction to strike down an offending land use restriction.
Babcock, Hope M.
core +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
White by Force and the Racialized State of Exception
Social SciencesWhite identity is forged through violence. The moment that whites aspired to be white, they set themselves up for immediate, inevitable failure: they try to inhabit an identity of superiority that cannot exist, and this sets them into a perpetual ...
Vincent Jungkunz
doaj +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Zeitschrift für Politikwissenschaft, 2018 During the escalation of the “German Autumn” in 1977 the Federal German government resorted to a specific form of crisis management that had been described as an undeclared state of exception. It was Federal chancellor Helmut Schmidt in the first place who oversaw the anti-terrorist measures in the situation room where the executive branch ruled for ...
openaire +2 more sources