Results 91 to 100 of about 1,394,346 (266)

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

A novel chassis for high-quality recombinant protein expression: apoptosis pathway engineering via multi-gene knockout and efficacy improvement of CHO cells

Journal of Biological Engineering
Background Chinese hamster ovary (CHO) cells are pivotal in biopharmaceutical production, yet balancing high recombinant protein yield with cell survival remains challenging.
Youzhi Wu, Ying Cao, Zexuan Guo, Yanhua Ma, Xiaohui Zan, Xingjin Gu, Fan Zhang, Chunxia Chai, Rui Nui, Qiang Shang, Wei Wang   +10 more
doaj   +1 more source

Effects of Phenanthrene Soil Pollution on Cadmium Bioaccumulation and Metabolic Responses in Maize (Zea mays L.)

Agriculture
Co-contamination of cadmium (Cd) and polycyclic aromatic hydrocarbons (PAHs) in agricultural soils poses a critical threat to crops and food safety, but how PAHs affect Cd uptake and plant metabolism is still unclear.
Guangwei Zhang, Guohui Ning, Yukun Zhang, Qingyu Meng, Jiahui Li, Mingyue Qi, Liqian Chen, Liang Mi, Jiayuan Gao, Meng Zhang, Xiaoxue Zhang, Xiaomin Wang, Zhixin Yang   +12 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Evaluation of drought-tolerant varieties based on root system architecture in cotton (Gossypium hirsutum L.)

BMC Plant Biology
Background Root system architecture (RSA) exhibits significant genetic variability and is closely associated with drought tolerance. However, the evaluation of drought-tolerant cotton cultivars based on RSA in the field conditions is still underexplored.
Congcong Guo, Lingxiao Zhu, Hongchun Sun, Qiucheng Han, Shijie Wang, Jijie Zhu, Yongjiang Zhang, Ke Zhang, Zhiying Bai, Anchang Li, Liantao Liu, Cundong Li   +11 more
doaj   +1 more source

State by State Comparison of Insurance Regulations [PDF]

JNCI: Journal of the National Cancer Institute, 2006
openaire   +2 more sources

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

C-Phycocyanin ameliorates ovarian hyperstimulation syndrome by mitigating inflammation and enhances fertility in an OHSS mouse model

Journal of Ovarian Research
Background Ovarian hyperstimulation syndrome (OHSS) is a serious complication of assisted reproductive technology, particularly during gonadotropin-induced superovulation in in vitro fertilization and embryo transfer.
Chun-Ru Song, Zhao-Yu Jiang, Teng Wang, Xiao-Jie Zhang, Fang-Rui Xue, Yan-Yan Zhao, Dui Sun, Meng-Lei Feng, Qi Yang, Kang Ding, Cheng-Guang Liang   +10 more
doaj   +1 more source