Results 101 to 110 of about 1,394,346 (266)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

CAM regulation in the United States

Complementary Therapies in Medicine, 2002
As complementary and alternative medical (CAM) therapies increasingly penetrate conventional health care, physicians and other health care providers find themselves providing (or being asked to provide) care at the borderland of medicine, ethics, public policy and law. Whereas historically, many physicians and patients shunned a dialogue concerning use
openaire   +2 more sources

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Decreased expression of ribonucleotide reductase M2 accelerates ovarian aging by suppressing cell proliferation and inducing DNA damage in mouse theca-interstitial cells

Journal of Ovarian Research
Natural aging affects the ovary, leading to declining function and age-related female infertility. This study investigated the role of theca-interstitial cells (TICs) in ovarian aging, a previously understudied area.
Rula Sa, Xiang Zhang, Kesong Shi, Baoluri Wang, Haiquan Yu   +4 more
doaj   +1 more source

Biocontrol Potential of Bacillus subtilis A3 Against Corn Stalk Rot and Its Impact on Root-Associated Microbial Communities

Agronomy
Fusarium stalk rot (FSR), a devastating soil-borne disease caused by Fusarium species, severely threatens global maize production through yield losses and mycotoxin contamination.
Liming Wang, Shiqi Jia, Yue Du, Hongzhe Cao, Kang Zhang, Jihong Xing, Jingao Dong   +6 more
doaj   +1 more source

Membrane Processing and Steady-State Regulation of the Alternative Peroxisomal Import Receptor Pex9p. [PDF]

Front Cell Dev Biol, 2020
Rudowitz M, Erdmann R, Schliebs W.
europepmc   +1 more source

Regulating Regulators: The Legal Environment of the State

The University of Toronto Law Journal, 1990
In this paper I focus on the ability of tort law to reduce primary costs, or losses associated with the number and seriousness of accidents. In one sense I will be analysing the state as if it were a private firm in which losses suffered by private individuals and firms are externalities.
openaire   +2 more sources

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Increased rumen Prevotella enhances BCAA synthesis, leading to synergistically increased skeletal muscle in myostatin-knockout cattle

Communications Biology
Myostatin (MSTN) is a negative regulator of muscle growth, and its relationship with the gut microbiota is not well understood. In this study, we observed increase muscle area and branched-chain amino acids (BCAAs), an energy source of muscle, in ...
Chao Hai, Zhenting Hao, Lige Bu, Jiaru Lei, Xuefei Liu, Yuefang Zhao, Chunling Bai, Guanghua Su, Lei Yang, Guangpeng Li   +9 more
doaj   +1 more source