Results 51 to 60 of about 1,232,717 (325)

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Required Velocity Calculation in the Presence Of Atmosphere Effect in C* Matrix [PDF]

open access: yesفصلنامه علوم و فناوری فضایی, 2011
In this research a perturbation based guidance method is developed for non-Keplerian problem. Problem is linearized in the presence non-gravitational forces like aerodynamic, so it can improve the performance of C* guidance for reentry problems.
A. Mohammadi   +3 more
doaj  

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

Research on Disability Grading Based on ICF Functional Framework: Empirical Evidence From Zhejiang Province, China

open access: yesFrontiers in Public Health, 2021
Through assignment method, the total score of disability in multiple dimensions is obtained, and it is divided into five functional states—severe disability, partial disability, moderate disability, mild disability, and health—according to the score, and
Huan Liu
doaj   +1 more source

Inverse Transformation of Elliptical Relative State Transition Matrix

open access: yesInternational Journal of Astronomy and Astrophysics, 2014
A new set of relative orbit elements (ROEs) is used to derive a new elliptical formation flying model in previous work. In-plane and out-of-plane relative motions can be completely decoupled, which benefits elliptical formation design. In order to study the elliptical control strategy and perturbation effects, it is necessary to derive the inverse
Jianfeng Yin, Yinrui Rao, Chao Han
openaire   +2 more sources

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

open access: yesFEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai   +4 more
wiley   +1 more source

Evaluation of Particle Density Using State Transition Matrix

open access: yesJournal of the Visualization Society of Japan, 2002
This study evaluates particle density distribution images in a pipe cross-section by means of the state transition matrix that is a parameter to indicate the dominant change among CT space-time frames. It is clarified a linear or a non-linear of the particle density change in the time and space.
TSUTSUMI, Yoshihito   +5 more
openaire   +2 more sources

An SMT-Based Approach to Bounded Model Checking of Designs in State Transition Matrix

open access: yesIEICE Trans. Inf. Syst., 2011
State Transition Matrix (STM) is a table-based modeling language that has been frequently used in industry for specifying behaviors of systems. Functional correctness of a STM design (i.e., a design developed with STM) could often be expressed as ...
W. Kong   +5 more
semanticscholar   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

open access: yesFEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Novel Approach of Multistate Markov Chains to Evaluate Progression in the Expanded Model of Non-alcoholic Fatty Liver Disease

open access: yesFrontiers in Applied Mathematics and Statistics, 2022
A global increase in the prevalence of obesity and type 2 diabetes is strongly connected to an increased prevalence of non-alcoholic fatty liver disease (NAFLD) worldwide.
Iman M. Attia
doaj   +1 more source

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