Results 61 to 70 of about 27,062 (355)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Measurement-Based Analysis of Static Var Compensator Effects in Industrial Rolling Mill Grids

Energies
Power quality is a continuous concern in industry, especially in steel mills operating with nonlinear, fluctuating, and unbalanced loads. This paper investigates the influence of a Static Var Compensator (SVC) on power quality parameters in a hot ...
Petru Ivascanu, Manuela Panoiu, Caius Panoiu   +2 more
doaj   +1 more source

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez, Everton G. Melo, Isadora C. B. Pavan, Percíllia V. S. Oliveira, Luiza B. C. T. Coimbra, Thaís L. S. Araujo   +5 more
wiley   +1 more source

Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays

FEBS Open Bio, EarlyView.
We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul, Alan Strunga, Jiri Damborsky, Zbynek Prokop   +3 more
wiley   +1 more source

Improving the Operation of Transmission Systems Based on Static Var Compensator

Electricity
This study evaluates and compares centralized and distributed reactive power compensation strategies using Static Var Compensators (SVCs) to enhance the performance of a high-voltage transmission system in the Caribbean region of Colombia.
Kelly M. Berdugo Sarmiento, Jorge Iván Silva-Ortega, Vladimir Sousa Santos, John E. Candelo-Becerra, Fredy E. Hoyos   +4 more
doaj   +1 more source

Enhanced performance of substation dynamics during large induction motor starting using SVC

Alexandria Engineering Journal, 2018
Static Var Compensators (SVC) have been widely used to separately improve each of voltage variation performance and steady state power factor of industrial substations. However, these two functions are interdependent, power factor improvement tends to do
Ahmed S. Omran, Nabil H. Abbasy, Ragi A. Hamdy   +2 more
doaj   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

IMPROVEMENT OF POWER AND VOLTAGE QUALITY IN POWER SYSTEM DISTRIBUTION USING FACTS (SVC & DSTATCOM)

Diyala Journal of Engineering Sciences, 2015
Power quality is one of the important fields in the electrical power and distribution system. In order to reduce the power losses and improve voltage level in electrical power and distribution system, Flexible AC Transmission Systems (FACTS) devices ...
Ali Najim Abdullah
doaj  

Nonlinear Coordinated Passivation Control of Single Machine Infinite Bus Power System with Static Var Compensator [PDF]

, 2021
Salma Keskes, Souhir Salleem, Larbi Chrifi‐Alaoui, Mohamed Ben Ali Kammoun   +3 more
openalex   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source