Results 121 to 130 of about 124,347 (217)

Statins enhance trastuzumab deruxtecan efficacy: preclinical synergy in HER2-negative models and clinical benefit in HER2-positive metastatic breast cancer. [PDF]

Exp Hematol Oncol
Sahin TK, Orhan C, Ozercan IH, Muglu H, Er B, Akyildiz A, Tunbekici S, Oruc A, Aykan MB, Koylu B, Akdogan O, Onur ID, Ates O, Yazici O, Selcukbiricik F, Karadurmus N, Araz M, Erdem D, Goker E, Bilici A, Aksoy S, Guven DC.   +21 more
europepmc   +1 more source

Circulating Omega‐3 Fatty Acids and Cardiometabolic Outcomes: A Systematic Review of Publications From UK Biobank

Lipids, EarlyView.
ABSTRACT Studies have shown that omega‐3 fatty acids may protect against cardiovascular diseases (CVDs) and related metabolic conditions. UK Biobank is a large cohort study that includes data on plasma omega‐3 fatty acids at study entry and health outcomes during the follow‐up period.
Warda Tul Firdous, Philip C. Calder
wiley   +1 more source

Lipophilic Statins Deplete GPX4 to Promote Ferroptosis and Sensitize Cancer Cells to Immune Checkpoint Blockade. [PDF]

Mol Cancer Ther
Talty R, Brooks VT, McGeary MK, Milette S, Zheng S, Flem-Karlsen K, Daniels A, Deshmukh M, Park K, Caraccio W, Yan H, Echeandia-Francis C, McNamara M, Hong S, Kirwin DS, Olino K, Johnson CH, Bosenberg M, Micevic G, Roy SF.   +19 more
europepmc   +1 more source

Stroke Following Facial Laser Resurfacing Procedure—A Case Report

Lasers in Surgery and Medicine, EarlyView.
ABSTRACT Objectives To describe the first reported case of embolic stroke with hemorrhagic conversion following a dermatologic energy‐based device procedure, highlighting its mechanism and clinical implications. Methods A detailed case review was conducted, including clinical presentation, imaging, and subsequent diagnostic workup. The patient provided
Tal Levy, Joel L. Cohen
wiley   +1 more source

Impact of Statin Therapy on Clinical Outcomes of Patients Hospitalised with Skin and Soft Tissue Infections. [PDF]

J Clin Med
Wee YC, Hewage U, Horwood C, Sharma Y.
europepmc   +1 more source

Proteomics of Nitrotyrosine: Integrating Mass Spectrometry and Immunodetection in Redox‐Driven Pathology

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Nitrooxidative stress, driven by excess reactive nitrogen species like peroxynitrite, contributes to the pathogenesis of many chronic diseases. Among its molecular footprints, 3‐nitrotyrosine (3NT) has emerged as a biologically relevant marker of protein nitration.
Brîndușa Alina Petre
wiley   +1 more source

The impact of statin therapy on the prognosis of hormone receptor-positive breast cancer: a systematic review and meta-analysis. [PDF]

Front Oncol
Ma X, Sun Y, Qi Y, Qu H, Zhang F.
europepmc   +1 more source

Proteomic Signatures of Ectopic Fat Distribution: Tissue‐Specific Drivers and Clinical Implications

Med Research, EarlyView.
Integration of plasma proteomics and multi‐organ MRI in 666 UK Biobank participants, combined with a knockoff‐based causal inference and machine learning framework, reveals organ‐specific drivers of ectopic fat: PLA2G1B (pancreas), ERBB2/IGFBP2 (liver), CA14 (muscle), and NCAM2/TNFRSF10B (pericardium). These drivers engage distinct pathways (e.g., PI3K‐
Bing Zhang, Fen Yang, Xingji Lian, Jie He, Shuijin Huang, Mingjuan Fan, Yin Liang, Jiaqiang Huang, LongYan Yin, Hong Wang   +9 more
wiley   +1 more source

ROLE OF STATINS IN CIRRHOTIC PORTAL HYPERTENSION: META-ANALYSIS OF RANDOMIZED STUDIES. [PDF]

Arq Gastroenterol
Moreno MOA, Paz CLDSL, Rodrigues MAN, Andrade ACD, Dezan MGF, Cavalcante LN, Lyra AC.   +6 more
europepmc   +1 more source

Elevation of Stearoyl‐Coenzyme A Desaturase and Monounsaturated Fatty Acids in Parkinson's Disease Serum

Movement Disorders, EarlyView.
Abstract Background Emerging evidence indicates that dysregulation of monounsaturated fatty acids (MUFAs), synthesized by the enzyme stearoyl‐coenzyme A desaturase (SCD), impacts on α‐synuclein pathology in the Parkinson's disease (PD) brain. Objective The objective of this study was to analyze SCD and MUFA‐enriched lipids in the periphery of patients ...
Finula I. Isik, Russell Pickford, Michelle Chua, Simon J.G. Lewis, Nicolas Dzamko, Woojin Scott Kim   +5 more
wiley   +1 more source