Results 171 to 180 of about 119,942 (261)

Inaccurate information regarding cardiovascular disease prevention enabled by generative artificial intelligence. [PDF]

Am J Prev Cardiol
Al-Dalakta A, Honnekeri B, Rodriguez F, Laffin L, Sunder V, Bruemmer D, Cho L, Nissen SE, Sarraju A.   +8 more
europepmc   +1 more source

Elevation of Stearoyl‐Coenzyme A Desaturase and Monounsaturated Fatty Acids in Parkinson's Disease Serum

Movement Disorders, EarlyView.
Abstract Background Emerging evidence indicates that dysregulation of monounsaturated fatty acids (MUFAs), synthesized by the enzyme stearoyl‐coenzyme A desaturase (SCD), impacts on α‐synuclein pathology in the Parkinson's disease (PD) brain. Objective The objective of this study was to analyze SCD and MUFA‐enriched lipids in the periphery of patients ...
Finula I. Isik, Russell Pickford, Michelle Chua, Simon J.G. Lewis, Nicolas Dzamko, Woojin Scott Kim   +5 more
wiley   +1 more source

Extracellular vesicles related to familial hypercholesterolemia. [PDF]

Arch Endocrinol Metab
Silvino JPP, Jannes CE, Pestana RMC, Silvino LPP, Silva IFO, Teixeira-Carvalho A, Gomes KB.   +6 more
europepmc   +1 more source

Observational Evaluation of Muscle Echointensity and EMG Insertional Activity in Poststroke Spasticity

Muscle &Nerve, EarlyView.
ABSTRACT Introduction/Aims When spasticity occurs after a stroke, peripheral changes in spastic muscle architecture may develop. The primary objective was to determine if an association exists between spastic muscle echointensity (EI) measured by the Modified Heckmatt Scale (MHS) and changes in insertional activity detected by electromyography (EMG ...
Rajiv Reebye, Ève Boissonnault, April Jeon, Mirko Filippetti, Gina McKernan, Oluwasanmi O. Adenaiye, Alessandro Picelli, Michael C. Munin   +7 more
wiley   +1 more source

Association of Glucagon‐Like Peptide‐1 Receptor Agonists With Cancer Risk in Older Adults With Type 2 Diabetes

Obesity, EarlyView.
ABSTRACT Objective The real‐world evidence on the association between glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs) and cancer risk remains limited and mixed. Methods In 2013–2020 national Medicare claims data, we included cancer‐naïve patients with type 2 diabetes (T2D). We identified those who initiated GLP‐1 RA, sodium‐glucose cotransporter 2
Ying Lu, Hao Dai, Huilin Tang, William T. Donahoo, Thomas J. George, Ramon C. Sun, Sizun Jiang, Aik Choon Tan, Yi Guo, Jonathan D. Licht, John M. Allen, Kelvin P. Lee, Jingchuan Guo, Jiang Bian   +13 more
wiley   +1 more source

The heterogeneous treatment effects of statins on dementia: a target trial emulation with causal machine learning using integrated genetic and real-world data. [PDF]

Alzheimers Dement
Lai Y, Her QL, Zhang Y, Xu H, Kucharska-Newton A, Ji D, Wu G, Garden G, Stürmer T, Wang T, Xu Y.   +10 more
europepmc   +1 more source

Comprehensive Insights into Natural Bioactive Compounds: From Chemical Diversity and Mechanisms to Biotechnological Innovations and Applications

ChemistryOpen, EarlyView.
Natural products derived from plants, animals, fungi, bacteria, and minerals contain diverse bioactive classes such as alkaloids, flavonoids, terpenoids, saponins, tannins, and phenolics. These natural products work through different mechanisms, including ROS inhibition, NF‐κB suppression, and cytokine regulation, and exhibit wide applications across ...
Sajid Ali, Atif Ali Khan Khalil, Muhammad Saeed Akhtar, Adnan Amin, Wajid Zaman   +4 more
wiley   +1 more source

Association between statin therapy as primary prevention and mortality in adults 50 years and older with chronic kidney disease without other indications. [PDF]

Scand J Prim Health Care
Malmquist J, Davidge J, Bjurström K, Halling A, Agvall B.   +4 more
europepmc   +1 more source

Computational Evaluation of Statin Analogs Targeting HMG‐CoA Reductase for Coronary Artery Disease Treatment

ChemistryOpen, EarlyView.
Molecular dynamics analysis of novel statin analogs shows that binding induces superior stabilization of HMG‐CoA reductase. As shown by the solvent‐accessible surface area profile, ligand‐induced rigidity offers a new, effective strategy for drug design. Cardiovascular diseases remain a leading cause of global mortality.
Yoshua B. Mtulo, Geradius Deogratias, James E. Mgaya, Andrew S. Paluch, Lucas Paul   +4 more
wiley   +1 more source