Results 201 to 210 of about 154,404 (310)

Comprehensive Insights into Natural Bioactive Compounds: From Chemical Diversity and Mechanisms to Biotechnological Innovations and Applications

ChemistryOpen, EarlyView.
Natural products derived from plants, animals, fungi, bacteria, and minerals contain diverse bioactive classes such as alkaloids, flavonoids, terpenoids, saponins, tannins, and phenolics. These natural products work through different mechanisms, including ROS inhibition, NF‐κB suppression, and cytokine regulation, and exhibit wide applications across ...
Sajid Ali, Atif Ali Khan Khalil, Muhammad Saeed Akhtar, Adnan Amin, Wajid Zaman   +4 more
wiley   +1 more source

When the Target Is Not the Driver: Rethinking LDL in Cardiac Allograft Vasculopathy. [PDF]

Circulation
Truby LK, Shapiro MD.
europepmc   +1 more source

Statine [PDF]

, 2020
openaire   +1 more source

Computational Evaluation of Statin Analogs Targeting HMG‐CoA Reductase for Coronary Artery Disease Treatment

ChemistryOpen, EarlyView.
Molecular dynamics analysis of novel statin analogs shows that binding induces superior stabilization of HMG‐CoA reductase. As shown by the solvent‐accessible surface area profile, ligand‐induced rigidity offers a new, effective strategy for drug design. Cardiovascular diseases remain a leading cause of global mortality.
Yoshua B. Mtulo, Geradius Deogratias, James E. Mgaya, Andrew S. Paluch, Lucas Paul   +4 more
wiley   +1 more source

Circulating Profiles of the Bile Acid Metabolomics in Patients With Polycystic Ovary Syndrome Treated With Metformin or Canagliflozin

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, EarlyView.
ABSTRACT Objective Bile acids are indispensable modulators in the development of polycystic ovary syndrome (PCOS). Our previous study identified that metformin and canagliflozin have similar efficacy in patients with PCOS combined with insulin resistance (IR).
Qi Yan, Meili Cai, Nan Wang, Wenhao Wu, Hua Zhang, Yikun Zhu, Jing Luo, Manna Zhang, Jin Li   +8 more
wiley   +1 more source

The Effect of Statins on Bleeding in Isolated Coronary Artery Bypass Grafting Statins in CABG. [PDF]

J Clin Med
Karaarslan M, Beyazal OF, Kayalar N, Yanartas M.   +3 more
europepmc   +1 more source

Nanoemulsions for Skin Delivery of Essential Oils: A Systematic Review

Phytotherapy Research, EarlyView.
ABSTRACT Essential oils (EOs) are recognized for their multiple health benefits. However, their high volatility, low stability, and limited water solubility limit their effective application. This systematic review aims to assess the use of nanoemulsions as delivery systems for the topical administration of EOs, highlighting their efficacy, safety, and
Thais Leticia Moreira da Silva, Anna Claudia Morais de Oliveira Capote, Flávio Luís Beltrame, Priscileila Colerato Ferrari   +3 more
wiley   +1 more source

Convergent Metabolic Pathways in MASH Therapeutics: An AMPK-Centric Analysis. [PDF]

J Cell Mol Med
Choi S, Jung JS, Seo YS, Song S, Ham J, Chung H, Ramadan Y, Choi K.   +7 more
europepmc   +1 more source

Long‐term remission in gout: Challenges and future opportunities

Rheumatology &Autoimmunity, EarlyView.
Prolonged hyperuricemia is a major risk factor for gout, which is now regarded as a curable disease. Awareness of the various factors that can trigger gout flares is essential for their prevention. An important determinant of treatment decisions and long‐term follow‐up is the quality of the clinician–patient relationship. The “treat‐to‐target” approach
Patapong Towiwat, Zhanguo Li
wiley   +1 more source

Human genetics suggests differing causal pathways from HMGCR inhibition to coronary artery disease and type 2 diabetes. [PDF]

Int J Epidemiol
Hwang S, Karhunen V, Patel A, Lockhart SM, Carter P, Whittaker JC, Burgess S.   +6 more
europepmc   +1 more source