Results 61 to 70 of about 22,583 (293)

CypD Dependent mPTP Opening Is Crucial for Oxidized Mitochondrial DNA Release in Ferroptosis

Advanced Science, EarlyView.
Ferroptosis is driven by mitochondrial permeability transition pore (mPTP) opening, which induces mitochondrial swelling and releases oxidized mitochondrial DNA. The released mtDNA activates cGAS–STING signaling, promotes ferritinophagy, and amplifies ferroptotic cell death. Disruption of mtDNA repair sensitizes tumors to ferroptosis in vivo, revealing
Hong Zhou, Wan Fu, Shizuo Liu, Zili Zhang, Hanyan Luo, Qing Zhong   +5 more
wiley   +1 more source

Perspektif Rusia Tentang Hubungan Internasional Pasca Perang Dingin

Jurnal Ilmiah Hubungan Internasional, 2017
After the Soviet break-up and the Marxist regime collapsed, many of alternative notions emerged in the academic community in Russia, including alternative ideas in the field of International Relations (IR).
Umar Suryadi Bakry
doaj   +1 more source

Spatiotemporal Sequential Delivery of Chidamide Regulates Macrophage Reprogramming in Lymphoma Microenvironment Through HDACs‐STAT3 Pathway

Advanced Science, EarlyView.
Our study identifies the HDACs‐STAT3 axis as key regulator for M2 macrophage accumulation in DLBCL. We developed Chid@M2pep‐EVs/TP, a pH‐responsive drug delivery system for M2 macrophage specific chidamide administration. By coupling M2‐targeted chidamide with EVs‐mediated delivery, this system reprograms M2 to M1 via HDAC inhibition and STAT3 ...
Bo Dai, Shuo Wang, Xiaotong Peng, Kunpeng Wu, Mengyao Wu, Zhaoning Lu, Haoshu Zhong, Xiaohan Qian, Shuiyi Tan, Hui Yang, Tanlezi Sun, Jing Wang, Jie Zhang, Hua Jiang, Yin Tong, Tong Chen   +15 more
wiley   +1 more source

THE INFLUENCE OF POLITICAL CULTURE ON THE LEGITIMACY OF LEGISLATIVE POWER IN MODERN RUSSIA

Вестник Кемеровского государственного университета, 2015
Political culture is the connecting link between the interests, needs, norms, and social status of the subjects of the political process and their political behaviour.
S. V. Ivlev
doaj  

Expanding Statism through Sovereign Investment? Evidence from the Domestic-Focused Indonesia Investment Authority

Jurnal Hubungan Internasional
This study examined Indonesia’s first-ever sovereign wealth fund (SWF), known as the Indonesia Investment Authority (INA), focusing on domestic investment.
Raras Cahyafitri
doaj   +1 more source

Bufalin Inhibits the PI3K/AKT Pathway by Targeting GTF3C4 to Impede Breast Cancer Progression

Advanced Science, EarlyView.
Mechanisms of Bufalin‐Mediated Intervention in Breast Cancer. ABSTRACT Breast cancer incidence is rising globally, presenting challenges such as treatment side effects and drug resistance. Bufalin is a bufadienolides compound with potential anti‐cancer effects. This study shows that bufalin inhibits malignant proliferation of MDA‐MB‐231 and MCF‐7 cells
Siyu Guo, Xiaodong Chen, Haojia Wang, Jiying Zhou, Peiying Lu, Jiangying Liu, Keyan Chai, Jingyuan Zhang, Siyun Yang, Shan Lu, Yifei Gao, Zhengsen Jin, Xiaoyu Tao, Zhongdong Hu, Qinglin Li, Jiarui Wu   +15 more
wiley   +1 more source

State Civilisation: The Statist Core of Vladimir Putin’s Civilisational Discourse and Its Implications for Russian Foreign Policy

Politics in Central Europe, 2016
The essay examines Vladimir Putin’s civilisational discourse, which arose in earnest with the publication of his presidential campaign articles in 2012.
Linde Fabian
doaj   +1 more source

Evaluation of the Space Stat 30 sodium/potassium ion analyzer. [PDF]

, 1978
S Patal, Peter O’Gorman
openalex   +1 more source

A Novel Function of Nonadecanoic Acid in Regulating Glucose Homeostasis

Advanced Science, EarlyView.
This study identifies the odd‐chain fatty acid C19:0 as an endogenous ligand of GPR120 that promotes glucose homeostasis via Gαq signaling. In obesity, elevated palmitic acid suppresses endogenous C19:0 production through a miRNA–PPARα–HACL1 pathway, offering a promising direction for understanding the role of OCFAs in human health.
Yanting Hou, Yinghua Ma, Qin Liu, Dingling Ma, Yuxin Tong, Lili Xu, Xiaolong Chu, Jingzhou Wang, Maodi Liang, Mengyuan Zhao, Huizi Zhang, Yurui Su, Jianxin Xie, Cuizhe Wang, Jun Zhang   +14 more
wiley   +1 more source

Globalization's Problematic for Labour: Three Paradigms

Global Labour Journal, 2009
Globalization's impact on workers worldwide is contested. The nature of labour's responses is similarly contested. To a significant degree this contestation arises because of different conceptualizations of 'globalization'.
Paul Bowles
doaj   +1 more source